Sentences with phrase «closely related gene»
They found striking recurrence of lysine - 27 mutations in H3F3A or the closely related gene HIST1H3B (which encodes H3.1) in 78 % of gliomas and 22 % of non-brainstem glioblastomas.
http://massgenomics.org/
ISIS - SMNRx is designed to treat all types of childhood SMA by altering the splicing of a closely related gene (SMN2) that leads to the increased production of fully functional SMN protein.
ISIS - SMNRx is designed to alter the splicing of a closely related gene (SMN2) to increase production of fully functional SMN protein.
Two other, very closely related genes (DFR - A and DRF - C) sit side - by - side, next to DFR - B.
Not exact matches
Fiers investigated the nucleotide sequence of the hemagglutinin gene of this duck virus and found that it was indeed very closely related to the strain that started the 1968 Hong Kong outbreak.
Apart from their introns, the versions of c - src found in fishes, birds and mammals are all closely related to the viral gene v - src and to one another.
When the team induced expression of the corresponding gene in the leaves of two other plant species (one closely related to S. lycopersicum and the other more distantly related), both plants reacted to presence of the C. reflexa peptide with increased production of ethylene, and exhibited increased resistance to C. reflexa infestation.
They downloaded sequences of more than 700 genes from organisms ranging from fruit flies to humans and compared genes from closely related species.
It has multiple hosts and can evolve by mutation but also reassortment (when two closely related strains infect the same host and exchange gene segments, producing new strains — a process distinct from mutation, when the RNA of a virus is miscoded during replication).
Remarkably, the maps derived from these two processes were closely related and converged on the same Parkinson's genes and cellular processes.
«The other major part of the story is that in mycorrhizal lineages there is a huge turnover in genes that are upregulated in the symbiosis - many of these have no homologs in even closely related species, suggesting that the evolution of the symbiosis is associated with massive genetic innovation.»
They also ruled out other possibilities, including the gene spontaneously mutating back to the normal form, the existence of more than two copies of the hothead gene, or closely related DNA sequences providing a template for repairs.
The two closely related regulatory genes are active in the normal development of mammals and govern how RNAs produced from the genes are joined to make final versions of the encoded protein, a process called alternative splicing.
High rates of marriage between closely related people there make it more likely that people will inherit two nonfunctional gene copies.
The Nature study also adds to what is known about how genes are transferred from one species to another when individuals from two closely related species mate.
Fascinatingly, however, the Cambridge - Sheffield study has now shown that exactly the same gene also influences the extremely bright and colourful patterns of Heliconius — the name given to about 40 different closely - related species of beautiful, tropical butterflies found in South America.
Castoe and his team used a similar genomic approach to understand gene flow in two closely related species of western rattlesnakes with an intertwined genetic history.
Both studies relied on a popular lab organism known as C. elegans, a nearly microscopic nematode that is fast growing, translucent and has a sequenced genome showing that nearly half its genes are closely related to corresponding human genes.
Michael Metzker, at the time a graduate student in the laboratory of Richard Gibbs at Baylor College of Medicine in Houston, compared the gene sequences of the strains to see how closely related they were, using a technique called phylogenetic analysis.
«To fully understand the loss of olfactory receptor genes in the ground tit, further comparisons need to be made with genomes of closely related species inhabiting lower altitudes.»
«Capturing introns: Targeting rapidly evolving regions of the genome for phylogenetics: New protocol for targeting intron - containing genes to resolve evolutionary relationships between closely related species.»
Around 40 percent of its genes are closely related to ours.
The researchers looked at those genes in seven M. rainbowi specimens from Kangaroo Island, five species of Moggridgea spiders from South Africa and seven species of southwestern Australia spiders from the closely related genus Bertmainius.
Biologists building family trees are likely being misled into suggesting that some organisms are closely related because genes and proteins are similar due to convergence, and not because the organisms had a recent common ancestor.
If Hamilton's hypothesis was correct, «successful» virtual robots were likely to be those that were closely related and shared food with each other; that would help to ensure that at least one of them — and some of the genes of both — would make it to the next round.
Just under half of the Bajau carry the version of this gene that is associated with larger spleen, compared with 6 percent of the Saluan and 3 percent of Han Chinese (a population chosen for comparison because they are not closely related to either group), he says.
Christine Mißbach, first author of the study, analyzed the active genes in the insect antennae where the olfactory receptors are located and describes her discovery this way: «Astonishingly, the firebrat, which is more closely related to flying insects, employs several co-receptors, while the odorant receptors themselves are absent.»
Other animals possess their own versions of FOXP2, suggesting that it might be possible to determine which evolutionary changes to the gene's DNA sequence are most closely related to our ability to talk.
Organisms from bacteria to humans share many closely related proteins, and thus genes.
By comparing the armadillo gene to other closely related mammals, a team of scientists has now identified several cone - related genes in the armadillo genome that became nonfunctional millions of years ago, they report today at the Society for Neuroscience conference in San Diego, California.
The possibility that H. erectus and modern humans interbred is all the more surprising, he adds, because most researchers think there is no evidence for our having swapped genes with the more closely related Neandertals.
Advancements in such genome sequencing have enabled the scientists to make comparisons of gene similarity between closely related species — wheat and barley, for example — and more distantly related species such as wheat and maize.
Originally, however, they were not examining brown fat thermogenesis, but instead were looking for clues to the function of ERRβ, a protein about which little was known at the time, except that it was closely related to ERRα, appeared in brown fat cells, and also worked as a so - called nuclear receptor — a molecular switch for gene activation that can be turned on by small lipophilic molecules or a signaling protein partner.
The gene HER2 is closely related to known lung cancer driver EGFR.
«The passage of one baculovirus gene to another probably only occurs between viruses that are very closely related,» says Guy Croizier of the French National Institute of Agronomic Research in Saint Christol - Les - Ales.
This sacrifice makes sense as the spiders in a nest are closely related and so share genes.
Researchers at the Senckenberg Nature Research Society and the Johannes - Gutenberg University Mainz have recently discovered that the raids required to achieve this are controlled by different genes in each of several closely related ant species of the genus Temnothorax.
Additionally, natural introgression between closely related species shows that genes common in one species are often deleterious when they introgress into a sister species.
Given that Dt2 is not the gene most closely related to AP1 and that semideterminacy is rarely seen in wild soybeans, Dt2 appears to be a recent gain - of - function mutation, which has modified the genetic pathways determining the stem growth habit in soybean.
«Their duplicated hybrid genome architectures provide these nematodes with multi-copy genes showing diverged sequence and expression patterns where their sexual relatives have very closely related alleles,» says Danchin.
About Splicing Splicing is a normal mechanism that the cell uses in order to produce many different, but closely related proteins from a single gene by varying the processing of the RNA.
Comparisons between the nucleotide makeup, or sequence, of particular genes allows scientists to see how closely they are related, and thus, group the organisms accordingly.
In addition, the researchers also found that bacteria that are closely related to one another have similar resistance genes, which might be expected as bacteria pass their genes from one generation to the next.
P21 is closely related to the tumor suppressor gene P53: cancer suppression and enhanced regeneration are frequently found to be opposite sides of the same coin.
The gene may have been passed along when two closely related species produced offspring together, she told Science News.
They also chose a gene target that might itself be problematic, given that it is part of a closely linked family of globin genes with highly related sequences, making it hard to target one without affecting the others.
The research thus suggests that the IRGM gene could play a role in influencing the overall makeup of an individual's microbiota, pushing it towards Prevotella dominance instead of an alternative community dominated by a closely related bacteria, Bacteroides.
Microarray analysis revealed temperature - dependent expression of distinct sets of genes, as well as 700 A. fumigatus genes not present or significantly diverged in the closely related sexual species Neosartorya fischeri, many of which may have roles in the pathogenicity phenotype.
Ant raids: It is all in the genes (07/03/2018) Researchers at the Senckenberg Nature Research Society and the University of Mainz recently discovered that the raids by slavemaker ants are controlled by different genes in each of several closely related ant species of the genus Temnothorax.
S2), whereas gene sampling among species with only one or a few sequences is focused on a few mitochondrial genes so that gene overlap is generally high among congeneric species and closely related genera.