Factor XII deficiency:
a clotting factor deficiency that rarely produces clinical signs.
A Korean team led by Director of the Center for Genome Engineering Jin - Soo Kim, Institute for Basic Science (IBS) and Professor Dong - Wook Kim at Yonsei University has experimented with hemoplia A-derived induced pluripotent stem cells (iPSCs) and hemoplia mice and found a way to correct this inversion and reverse
the clotting factor deficiency that causes hemophilia A.
Not exact matches
Patients with hemophilia A have a
deficiency of
clotting factor VIII (FVIII), while hemophilia B patients are deficient in
clotting factor IX (FIX).
The
deficiency in blood
clotting factor VIII is inherited and linked to the X chromosome.
Hemophilia A is an inherited bleeding disorder caused by a
deficiency of functioning
factor VIII (FVIII), a protein essential to
clotting.
Genetic
deficiencies can cause lowered plasma
clotting factor activity so as to compromise blood -
clotting; when a blood vessel is injured, a scab will not form and the vessel can continue to bleed excessively for a very long period of time.
It may also develop Von Willebrand's disease, a blood
clotting disorder that results from a
deficiency of the Von Willebrand
factor, an essential protein.
Blood -
clotting diseases include hemophilia B,
factor VII
deficiency, and von Willebrand's disease.
Factor I deficiency or hypofibrinogenemia: a rare deficiency of a clotting factor (fibrinogen), which causes excessive ble
Factor I
deficiency or hypofibrinogenemia: a rare
deficiency of a
clotting factor (fibrinogen), which causes excessive ble
factor (fibrinogen), which causes excessive bleeding.
Factor X
deficiency: a rare
clotting disorder primarily of American cocker spaniels.
Factor XI
deficiency: a rare
clotting disorder of several dog breeds.
Hemophilia A: a blood
clotting disorder due to
deficiency of coagulation
factor VIII (this is the most common type of hemophilia in dogs).
Factor IX deficiency or hemophilia B: same as hemophilia A, but more rare and involves a different clotting f
Factor IX
deficiency or hemophilia B: same as hemophilia A, but more rare and involves a different
clotting factorfactor.
Factor VIII
deficiency or hemophilia A: the most common severe inherited
clotting disorder of humans and nonhuman animals.
Blood -
clotting diseases include von Willebrand's,
factor II
deficiency, hemophilia A, and the more serious hemophilia B.
Golden Retrievers can also have an inherited
deficiency in one of the
clotting factors of the blood.
Hemophilia A is a
deficiency of coagulation
factor VIII, and is the most common inherited
clotting disorder in dogs.
Von Willebrand's disease is a
deficiency in the
clotting protein known as von Willebrand's
factor and most commonly occurs in the Doberman Pinscher, German Shepherd, Golden Retriever, Miniature Schnauzer, Pembroke Welsh Corgi, Standard Manchester Terrier, Standard Poodle, Scottish Terrier, Basset Hound and Shetland Sheepdog breeds.
Labrador Retrievers can also have an inherited
deficiency in one of the
clotting factors of the blood.
ACT - activated
clotting time (bleeding disorders) ACTH - adrenocorticotropic hormone (adrenal gland function) Ag - antigen test for proteins specific to a disease causing organism or virus Alb - albumin (liver, kidney and intestinal disorders) Alk - Phos, ALP alkaline phosphatase (liver and adrenal disorders) Allergy Testing intradermal or blood antibody test for allergen hypersensitivity ALT - alanine aminotransferase (liver disorder) Amyl - amylase enzyme — non specific (pancreatitis) ANA - antinuclear antibody (systemic lupus erythematosus) Anaplasmosis Anaplasma spp. (tick - borne rickettsial disease) APTT - activated partial thromboplastin time (blood
clotting ability) AST - aspartate aminotransferase (muscle and liver disorders) Band band cell — type of white blood cell Baso basophil — type of white blood cell Bile Acids digestive acids produced in the liver and stored in the gall bladder (liver function) Bili bilirubin (bile pigment responsible for jaundice from liver disease or RBC destruction) BP - blood pressure measurement BUN - blood urea nitrogen (kidney and liver function) Bx biopsy C & S aerobic / anaerobic bacterial culture and antibiotic sensitivity test (infection, drug selection) Ca +2 calcium ion — unbound calcium (parathyroid gland function) CBC - complete blood count (all circulating cells) Chol cholesterol (liver, thyroid disorders) CK, CPK creatine [phospho] kinase (muscle disease, heart disease) Cl - chloride ion — unbound chloride (hydration, blood pH) CO2 - carbon dioxide (blood pH) Contrast Radiograph x-ray image using injected radiopaque contrast media Cortisol hormone produced by the adrenal glands (adrenal gland function) Coomb's anti- red blood cell antibody test (immune - mediated hemolytic anemia) Crea creatinine (kidney function) CRT - capillary refill time (blood pressure, tissue perfusion) DTM - dermatophyte test medium (ringworm — dermatophytosis) EEG - electroencephalogram (brain function, epilepsy) Ehrlichia Ehrlichia spp. (tick - borne rickettsial disease) EKG, ECG - electrok [c] ardiogram (electrical heart activity, heart arryhthmia) Eos eosinophil — type of white blood cell Fecal, flotation, direct intestinal parasite exam FeLV Feline Leukemia Virus test FIA Feline Infectious Anemia: aka Feline Hemotrophic Mycoplasma, Haemobartonella felis test FIV Feline Immunodeficiency Virus test Fluorescein Stain fluorescein stain uptake of cornea (corneal ulceration) fT4, fT4ed, freeT4ed thyroxine hormone unbound by protein measured by equilibrium dialysis (thyroid function) GGT gamma - glutamyltranferase (liver disorders) Glob globulin (liver, immune system) Glu blood or urine glucose (diabetes mellitus) Gran granulocytes — subgroup of white blood cells Hb, Hgb hemoglobin — iron rich protein bound to red blood cells that carries oxygen (anemia, red cell mass) HCO3 - bicarbonate ion (blood pH) HCT, PCV, MHCT hematocrit, packed - cell volume, microhematocrit (hemoconcentration, dehydration, anemia) K + potassium ion — unbound potassium (kidney disorders, adrenal gland disorders) Lipa lipase enzyme — non specific (pancreatitis) LYME Borrelia spp. (tick - borne rickettsial disease) Lymph lymphocyte — type of white blood cell MCHC mean corpuscular hemoglobin concentration (anemia, iron
deficiency) MCV mean corpuscular volume — average red cell size (anemia, iron
deficiency) Mg +2 magnesium ion — unbound magnesium (diabetes, parathyroid function, malnutrition) MHCT, HCT, PCV microhematocrit, hematocrit, packed - cell volume (hemoconcentration, dehydration, anemia) MIC minimum inhibitory concentration — part of the C&S that determines antimicrobial selection Mono monocyte — type of white blood cell MRI magnetic resonance imaging (advanced tissue imaging) Na + sodium ion — unbound sodium (dehydration, adrenal gland disease) nRBC nucleated red blood cell — immature red blood cell (bone marrow damage, lead toxicity) PCV, HCT, MHCT packed - cell volume, hematocrit, microhematocrit (hemoconcentration, dehydration, anemia) PE physical examination pH urine pH (urinary tract infection, urolithiasis) Phos phosphorus (kidney disorders, ketoacidosis, parathyroid function) PLI pancreatic lipase immunoreactivity (pancreatitis) PLT platelet — cells involved in
clotting (bleeding disorders) PT prothrombin time (bleeding disorders) PTH parathyroid hormone, parathormone (parathyroid function) Radiograph x-ray image RBC red blood cell count (anemia) REL Rocky Mountain Spotted Fever / Ehrlichia / Lyme combination test Retic reticulocyte — immature red blood cell (regenerative vs. non-regenerative anemia) RMSF Rocky Mountain Spotted Fever SAP serum alkaline phosphatase (liver disorders) Schirmer Tear Test tear production test (keratoconjunctivitis sicca — dry eye,) Seg segmented neutrophil — type of white blood cell USG Urine specific gravity (urine concentration, kidney function) spec cPL specific canine pancreatic lipase (pancreatitis)-- replaces the PLI test spec fPL specific feline pancreatic lipase (pancreatitis)-- replaces the PLI test T4 thyroxine hormone — total (thyroid gland function) TLI trypsin - like immunoreactivity (exocrine pancreatic insufficiency) TP total protein (hydration, liver disorders) TPR temperature / pulse / respirations (physical exam vital signs) Trig triglycerides (fat metabolism, liver disorders) TSH thyroid stimulating hormone (thyroid gland function) UA urinalysis (kidney function, urinary tract infection, diabetes) Urine Cortisol - Crea Ratio urine cortisol - creatine ratio (screening test for adrenal gland disease) Urine Protein - Crea Ratio urine protein - creatinine ratio (kidney disorders) VWF VonWillebrands
factor (bleeding disorder) WBC white blood cell count (infection, inflammation, bone marrow suppression)