Sentences with phrase «clumps of amyloid»

That agent, aducanumab, is designed to bind preferentially to the early clumps of amyloid as they form plaques, and therefore may be more useful in mild or moderate patients who are already showing signs of memory loss and other cognitive problems.

The brains of individuals having Alzheimer's have clumps of amyloid plaques which are made up of aggregates of misfolded proteins.

«Though several studies have suggested that amyloid beta builds up when we lack sleep, and previous evidence has shown sleep may give the brain a chance to clear out clumps of amyloid beta, unfortunately none have been able to confirm that sleep deprivation can cause dementia.

«The small clumps of amyloid may be a key reason.

Scientists have long considered clumps of amyloid plaques — sticky, barnacle - like protein bundles — to be the first sign of Alzheimer's.

The brains of mice engineered to develop Alzheimer's disease were riddled with these plaques, clumps of amyloid - beta protein fragments, by the time the animals were 10 months old.

Not exact matches

After the night with disrupted sleep, the researchers found people had higher levels of beta - amyloid proteins, the proteins that clump together and form the plaque found in Alzheimer's - afflicted brains, in the volunteers» spinal fluid.

«The disability level aligned with the quantity of amyloid (protein clumps) present makes intuitive sense, but we were really amazed that the information from a small skin biopsy would correlate so well with disease severity,» says Polydefkis.

The idea for Smith's study was inspired by the work of co-author Alena Savonenko, M.D., Ph.D., associate professor of pathology, and her colleagues who showed that loss of serotonin neurons was associated with more protein clumps, or amyloid, in mouse brain.

Smith says her group is investigating whether PET imaging of serotonin could be a marker to detect progression of disease, whether alone or in conjunction with scans that detect the clumping protein known as amyloid that accumulates in the brains of those with Alzheimer's disease.

This was the first time this technology has been used on amyloid fibrils of the infectious prion, which are a special form of clumped - together proteins that form fibrils.

About 20 proteins share the ability to clump together to form distinctive «amyloid fibrils» that contribute to Alzheimer's, Creutzfeldt - Jakob disease, and a variety of lesser - known disorders.

Amyloid plaques are the toxic clumps of protein that cause damage to cells in the brains of people with Alzheimer's disease.

They then made amyloids by allowing copies of each peptide to clump together, adding zinc ions to help the process along.

Specifically, the release of a stress - coping hormone called corticotropin - releasing factor (CRF), which is widely found in the brain and acts as a neurotransmitter / neuromodulator, is dysregulated in AD and is associated with impaired cognition and with detrimental changes in tau protein and increased production of amyloid - beta — protein fragments that clump together and trigger the neurodegeneration characteristic of AD.

Aducanumab, an antibody made by the pharmaceutical company Biogen, binds to and clears clumps of β amyloid from the brain like many other antibodies that have been tested.

A definitive diagnosis of Alzheimer's includes dementia and two distortions in the brain: amyloid plaques, sticky accumulations of misfolded pieces of protein known as amyloid beta peptides; and neurofibrillary tangles, formed when proteins called tau clump into long filaments that twist around each other like ribbons.

Given these insights, amyloids» role in Alzheimer's may be much more complex than researchers thought years ago, when they first discovered the clumps, or plaque, in the brains of Alzheimer's patients during autopsy.

That variety cropped up in a different part of the brain than the other strains, and it also produced clumps of proteins akin to the amyloid plaques found in sporadic Creutzfeldt - Jakob disease, a fatal brain disease of unknown origin that usually affects those over age 55.

That vaccine, which included bits of beta - amyloid to arouse immune - system T cells, cleared the clumps, but it also provoked dangerous brain inflammation in several patients.

Researchers believe the disease progresses because of sticky clumps of beta - amyloid proteins that form and build up between neurons, eventually killing them.

For example, clumps of proteins called amyloid fibrils are thought to be the cause of Alzheimer's disease as well as several other devastating illnesses.

«It is the best source of fresh human brain tissue available at the moment,» says Jucker, who plans to scrutinize it carefully under the microscope for anything that might resemble tiny clumps or seeds of amyloid - β.

US researchers have discovered a link between sleep deprivation and a brain protein called beta - amyloid — the protein that «clumps» together in the brains of Alzheimer's patients.

Previously, other researchers reported that ApoE4 seemed to reduce the clearance of amyloid - β, the protein that clumps together to form the hallmark plaques of AD, from the brain in a mouse model.

Within two months, those derived from the Alzheimer's patients began secreting high levels of amyloid protein, which clumped together in the spaces between neurons, resembling the formation of plaques in a fully formed brain.

In recent years, scientists made the surprising discovery that seminal fluid harbors fragments of proteins that clump together, forming structures called amyloid fibrils.

Sup35 is a prion — a type of protein that can form tangled clumps known as amyloids.

Amyloid fibers, those clumps of plaque - like proteins that clog up the brains of Alzheimer's patients, have perplexed scientists with their robust structures.

Beta amyloid plaques can form when particular fragments of the amyloid precursor protein (APP), cleaved by the enzyme gamma secretase, clump together.

Amyloid protein forms clumps in the brains of patients, creating sticky plaques that lead to brain cell death.

As beta amyloid proteins intertwine, they form tangled clumps that block the passage of signals from cell to cell.

One study presented by Dr. Donald Weaver, from the Krembil Research Institute of the University of Toronto, found that an extract of maple syrup may help prevent the misfolding and clumping of two types of proteins found in brain cells - beta amyloid and tau peptide.