Sentences with phrase «cluster trial design»
Dr Gambhir said the team looked at whether a randomized control trial (RCT)-- where all people in the population have the same chance of being selected; or a stepped - wedge cluster trial design — which would give vaccine to healthcare workers and eventually treat all of them — is most safe and effective in evaluating a vaccine.
https://www.sciencedaily.com/ Not exact matches
Cluster trial with no apparent adjustment for design effect.
A formative study using participatory action research design will first be conducted, followed by a cluster - randomised trial utilising both qualitative and quantitative data collection methods.
Larger, well - designed studies, such as cluster randomized trials, are ultimately needed to confirm the effectiveness of this strategy,» writes Alice Y. Guh, M.D., M.P.H., and L. Clifford McDonald, M.D., of the Centers for Disease Control and Prevention, Atlanta.
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A pragmatic cluster randomized clinical trial of diabetes prevention strategies for women with gestational diabetes: design and rationale of the Gestational Diabetes» Effects on Moms (GEM) study
We inflated this sample size by a design effect of 1.18 to 210 infants per trial arm to allow for correlation between responses within the same cluster (that is, maternal and child health centre), 28 assuming an average cluster size of seven (the number of eligible mothers attending each centre) and an intracluster correlation coefficient of 0.03.
Eligible study designs include randomised controlled trials, cluster randomised controlled trials, staggered enrolment trials, stepped wedged trials, quasi-randomised trials, quasi-experimental trials, time series / interrupted time - series trials, preference trials, regression discontinuity trials and natural experiment studies with a parallel control group.
Where study authors have not dealt appropriately with the cluster design in their analyses, we will extract or calculate effect estimates and their standard errors (SEs) as for a parallel group trial, and adjust the SEs to account for the clustering (Donner 1980).
However, the potential of universal prevention in early childhood to improve mental health remains largely unexplored.2 5 7 We previously published short - term outcomes at toddler age11 of the first cluster randomised trial of a truly universal early parenting programme, Toddlers Without Tears, designed to be offered to all parents in the community and aiming to prevent externalising behaviours using anticipatory guidance before any developmental onset.
The design incorporated a large sample size and used a cluster randomized control trial, to take into account the clustering of students in schools.
Fortunately, conducting randomized trials over the decades, intervention researchers have produced numerous manual - guided, evidence - based treatments (EBTs) for depression, anxiety, and conduct in youth.2 Unfortunately, these treatments have not been incorporated into most everyday clinical practice.3 - 5 A common view is that the complexity and comorbidity of many clinically referred youths, whose problems and treatment needs can shift during treatment, may pose problems for EBT protocols, which are typically designed for single or homogeneous clusters of disorders, developed and tested with recruited youths who differ from patients seen in everyday clinical practice, and involve a predetermined sequence of prescribed session contents, limiting their flexibility.3 - 8 Indeed, trials testing these protocols against usual care for young patients in clinical practice have produced mixed findings, with EBTs often failing to outperform usual care.7, 9