But in practice, editing T cell genomes with CRISPR / Cas9 has proved surprisingly difficult, said Alexander Marson, PhD, a UCSF Sandler Fellow, and senior and
co-corresponding author of the new study.
Not exact matches
A possible binding site is only functional in less than one percent
of circumstances, says the
study's other
co-corresponding author Rohs, a professor
of biological sciences, chemistry, physics, and computer science who is also a faculty member in the
new USC Michelson Center for Convergent Bioscience.
In their
new study,
co-corresponding authors Wei Wang, PhD, professor in the departments
of Chemistry and Biochemistry and Cellular and Molecular Medicine, and Gary S. Firestein, MD, professor in the Department
of Medicine, investigated epigenetic patterns in fibroblast - like synoviocytes (FLS)-- a specialized type
of cell that lines the inside
of joints.
«Every
new technology is an opportunity for
studying cells and tissues in greater detail,» said Broad core institute member Aviv Regev, a
co-corresponding author on the paper, director
of the Klarman Cell Observatory (KCO) at the Broad and the institute's Cell Circuits Program, and — along with Broad institute member and Infectious Disease and Microbiome Program co-director Ramnik Xavier — a
co-corresponding author on the paper.