Not exact matches
«Basically, we used the modified guide RNA to bring a transcriptional activator to
work together with the Cas9 and delivered that complex to the region
of the genome we were interested in,» says
co-first author Hsin - Kai Liao
of the Belmonte laboratory.
To test the TG - 18 hydrogel, we exposed the gel to several different kinds
of environments mimicking conditions in arthritic joints,» said Nitin Joshi,
co-first author on the
work an Instructor
of Medicine at BWH.
«We found that migratory beekeeping influences the lifespan
of bees, but how this impacts health and honey bee aging is more complicated and often more influenced by the environment these colonies are in,» said Michael Simone - Finstrom, an NC State postdoctoral researcher during this research and
co-first author of the study who currently
works at the USDA honey bee research lab in Baton Rouge, La..
«We see a dose - response relationship between frequency
of night shift
work and type 2 diabetes, where the more often people do shift
work, the greater their likelihood
of having the disease, regardless
of genetic predisposition,» said
co-first author Céline Vetter, PhD who conducted this
work while at the Channing Division
of Network Medicine at BWH, along with
co-first author Hassan S. Dashti, PhD, RD. Vetter is now an assistant professor at the University
of Colorado, Boulder.
«In the future, such efforts could allow us to much better understand human - microbiome interactions, model malnutrition disorders and inflammatory diseases
of the gut, and perform personalized drug testing,» said
co-first author Alessio Tovaglieri, a Graduate Student at the Department
of Health Science and Technology at ETH Zurich in Switzerland, who performs his thesis
work on Ingber's team.
Thorold Theunissen, a postdoctoral fellow in Jaenisch's lab and
co-first author of the study, says «Our
work provides a rigorous set
of criteria for comparing naïve human stem cells to their counterparts in the early human embryo.
«In our mouse experiments, olive oil produced essentially identical effects as Plenish — more obesity than coconut oil, although less than conventional soybean oil — and very fatty livers, which was surprising as olive oil is typically considered to be the healthiest
of all the vegetable oils,» said Poonamjot Deol, an assistant project scientist
working in Sladek's lab and the
co-first author of the research paper.
«At present, there is no clinically approved glucose - responsive modified insulin,» says Matthew Weber, Ph.D.,
co-first author with Chou and Benjamin Tang, Ph.D., who performed the
work together while postdoctoral fellows at MIT in collaboration with senior
authors and MIT professors Robert Langer, Ph.D., and Daniel Anderson, Ph.D. «The development
of such an approach could contribute to greater therapeutic autonomy for diabetic patients.»
Jianhong Chen, PhD, a Senior Research Specialist in the Department
of Cancer Prevention and Control, is
co-first author on this
work.