We will use the unique set of mutations present in that individual's cancer, as a barcode or thumbprint that we can exploit as innovative diagnostics to monitor for cancer recurrence and diagnose it early,» explained Dr Iain Tan,
co-lead author of the study who is a Consultant Medical Oncologist at NCCS and also a clinician scientist at GIS.
«POLARIS continues to seek opportunities to work with leading local researchers to enable the transition of their research findings from bench to bedside,» explained Prof Patrick Tan from Duke - NUS who is
a co-lead author of the study and the Program Director of POLARIS.
To verify their idea, they teamed with experimental biologists Anna Kuchina,
co-lead author of the study, and Gürol Süel, co-lead investigator, both of the University of California at San Diego.
«The inhibition of KinA by 0F results in a «negative feedback loop,» which means the circuit output works to counteract the input that triggers it,» said Narula,
co-lead author of the study.
«That suggests these neurons are providing a copy of the motor command directly to the auditory system,» said David M. Schneider, Ph.D.,
co-lead author of the study and a postdoctoral fellow in Mooney's lab.
«It jibed nicely with our expectations,» said Anders Nelson,
co-lead author of the study and a graduate student in Mooney's lab.
«Our brains are three times larger, have many more cells and therefore more processing power than chimpanzee or monkey,» said Andre M.M. Sousa, a postdoctoral researcher in the lab of neuroscientist Nenad Sestan and
co-lead author of the study.
It fits with Herodotus» depiction of Scythian funerary rituals, whereby sacrificed horses represented gifts from allied tribes spread across the steppes,» says Dr. Pablo Librado, post-doctoral researcher at the Centre for GeoGenetics, University of Copenhagen, Denmark, and
co-leading author of the study.
It only vanished within the last 2,000 years,» adds Dr. Cristina Gamba, post-doctoral researcher at the Centre for GeoGenetics at the time of the study, and
co-leading author of the study.
They are among the worst P53 mutations to have,» said Sulagna Ghosh,
a co-lead author of the study.
Says Hákon Jónsson, PhD - student at the Centre for GeoGenetics,
co-leading author of the study: «The recent near extinction of the Przewalski's horse population resulted in the persistence of deleterious mutations in the population, following the same mechanism that once led to the accumulation of deleterious mutations in the genomes of domesticated horses.
«The consequences of excess diesel NOx emissions for public health are striking,» said Susan Anenberg,
co-lead author of the study and co-founder of Environmental Health Analytics LLC.
«Mouse models don't represent the full diversity of the human response,» said Joel W. Blanchard, a PhD candidate in the Baldwin laboratory who was
co-lead author of the study with Research Associate Kevin T. Eade.
Mitchell and Betar Gallant, a Ph.D. student in mechanical engineering, were
the co-lead authors of the study.
«First we need to understand how mammalian regeneration works in a natural setting, then comes the potential to create therapeutic treatments for humans,» said Thomas Gawriluk, postdoctoral scholar and
co-lead author of the study.
«This method lets us see the whole picture, like a three - dimensional model of the entire embryo at one time,» said Tan Nguyen, the other
co-lead author of the study.
«We have proof of principle that MurJ is actually a valid target because we showed that if we stop it from working, the cells will die within 10 minutes — very quickly,» said Natividad Ruiz, assistant professor of microbiology at The Ohio State University and
a co-lead author of the study.
«We're interested in how urban warming affects the ecology of insects and what implications that might have for understanding how global warming might impact insects outside of the city, «said Elsa Youngsteadt, an entomology research associate at NCSU and
co-lead author of the study.
Co-lead authors of the study are Jeremy Elman and Hwamee Oh, both of whom were postdoctoral researchers in Jagust's lab.
«From our present work we hope to one day identify a specific inhibitor of endogenous TORC2 which could also find use as an effective anti-cancer agent,» concludes Taiana Oliveira, a researcher in the group of Christiane Schaffitzel at the European Laboratory of Molecular Biology, in Grenoble, France, and third
co-lead author of the study.
«It's a planet by any of the typical definitions based on mass,» OSU astronomy professor Scott Gaudi,
co-lead author of the study, explained «but its atmosphere is almost certainly unlike any other planet we've ever seen just because of the temperature of its day side.»
«This FRB, like others detected, is thought to originate from outside of Earth's own Milky Way galaxy, which means their signal has travelled over many hundreds of millions of light years, through a medium that — while invisible to our eyes — can be turbulent and affected by magnetic fields,» Ryan Shannon from Australia's ICRAR - Curtin University,
the co-lead author of a study detailing the observation, said in a statement.
«These findings were really surprising and exciting to us because nobody knew anything about collagen VI in the brain,» said Jason Cheng, MD,
co-lead author of the study.
«It was striking to be able to directly measure and theoretically characterize the chemical structure of reaction intermediates in this complex system,» said Felix Fischer, Professor for Chemistry at the University of Berkeley California and
co-lead author of the study.
John C Mittermeier from Oxford University and
co-lead author of the study explains, «There is a debate in conservation as to whether the fact that we as humans like a particular species justifies conserving it, regardless of its importance from an ecological point of view.»
Not exact matches
As they
studied brain activity in the knockout mice, the researchers also found prominent changes in a receptor in the brain known as mGluR5 and other proteins that support the function
of neurons and synapses, said
co-lead author Xiaoming Wang, M.D., Ph.D., senior research associate in Duke's department
of pediatrics.
«Many people have genetic variants that put them at risk for type 1 diabetes,» explains
study co-lead author Jason Gaglia, M.D., M.M.Sc., an Assistant Investigator in the Section
of Immunobiololgy at Joslin.
«We found that healthy food stores within one mile
of their home was the only significant factor that reduced or slowed the progression
of calcium buildup in coronary arteries,» said Ella August, Ph.D.,
co-lead author who initiated the
study and clinical assistant professor
of epidemiology at the University
of Michigan in Ann Arbor.
Fleming and Ruth Doherty
of the University
of Edinburgh were
co-lead authors on the
study, with co-
authors from 12 international institutions.
«This work is the first attempt to quantify the overall risk
of POPs for the Arctic ecosystem and to define a ranking in order to highlight the most dangerous chemicals in the mixture,» said Sara Villa
co-lead author of the Environmental Toxicology and Chemistry
study.
«Our
study shows the significant impact
of adding carotid plaque measurement using vascular ultrasound and coronary calcium scoring with CT scan to our conventional assessment for cardiovascular disease,» says Roxana Mehran, MD, the
study's
co-lead author and Director
of Interventional Cardiovascular Research and Clinical Trials at the Zena and Michael A. Weiner Cardiovascular Institute at Mount Sinai Heart at Icahn School
of Medicine at Mount Sinai.
«Poor adherence with the Canadian pregnancy prevention guidelines means that Canada, inadvertently, is using pregnancy termination rather than pregnancy prevention to manage fetal risk from isotretinoin,» states lead
author Dr. David Henry, senior scientist at the Institute for Clinical Evaluative Sciences (ICES) and executive
co-lead of the Canadian Network for Observational Drug Effect
Studies (CNODES).
«We're looking at a picture
of the mantle but we don't know what the colors mean,» said Susannah Dorfman, MSU geoscientist and the
study's
co-lead author.
«This material could be used to help stabilize temperature,» said
study co-lead author Fan Yang, a postdoctoral researcher at Berkeley Lab's Molecular Foundry, a DOE Office
of Science User Facility where some
of the research was done.
They also highlight the need for more
studies of this nature to give us a better idea
of the cities and landscapes that are most affected now and also under additional greenhouse warming,» said
co-lead author Michael Oppenheimer, the Albert G. Milbank Professor
of Geosciences and International Affairs and the Princeton Environmental Institute at Princeton's Woodrow Wilson School and Department
of Geosciences.
«That's more than a hundred-fold increase,» says Paul Bierman, a geologist at the University
of Vermont who
co-led the new
study with his former graduate student and lead
author Luke Reusser, and geologist Dylan Rood at Imperial College, London.
«We realized that λ, which is rather large for water, was key to the uniqueness
of these liquids,»
study co-lead author John Russo says.
On a positive note: «Our research indicates that if a student can structure a consistent schedule in which class days resemble non-class days, they are more likely to achieve academic success,» said
study co-lead author Aaron Schirmer, an associate professor
of biology at Northeastern Illinois University.
«We found that the majority
of students were being jet - lagged by their class times, which correlated very strongly with decreased academic performance,» said
study co-lead author Benjamin Smarr, a postdoctoral fellow who
studies circadian rhythm disruptions in the lab
of UC Berkeley psychology professor Lance Kriegsfeld.
The genetic contribution
of each
of these ancestral populations is substantial,» adds
study co-lead author Arjun Biddanda
of Cornell.
«We can use expansion pathology to push conventional light microscopes beyond their current limits, which could have important applications in diagnostic pathology,» said the
study's
co-lead author, Octavian Bucur, MD, PhD,
of the Department
of Pathology and Cancer Research Institute at BIDMC, who is also a Ludwig Cancer Center Research Investigator.
«The fully defined nature
of these synthetic bioengineered hydrogels could make them ideal for use in human patients in the event that HIOs are used for therapy in the future,» said Miguel Quirós, a University
of Michigan postdoctoral fellow and
co-lead author in the
study.
«Most
of the time, when people talk about delaying gratification, they talk about basic processes
of evaluation and self - control,» said Laura Michaelson, a CU - Boulder doctoral student in the Department
of Psychology and Neuroscience and
co-lead author of the new
study appearing in the online journal Frontiers in Psychology.
«Here we use electrostatic doping to control the atomic configuration
of a two - dimensional material,» said
study co-lead author Ying Wang, another graduate student in Zhang's lab.
«Taken together, these
studies show that the NK cell IL - 10 response is associated with extensive proliferation, either under in vitro conditions independent
of infection, or in vivo during infection,» wrote the
authors, including
co-lead author and former Brown postdoctoral researcher Seung - Hwan Lee, who is now at the University
of Ottawa.
«The idea
of electron doping to alter a material's atomic structure is unique to 2 - D materials, which are much more electrically tunable compared with 3 - D bulk materials,» said
study co-lead author Jun Xiao, a graduate student in Zhang's lab.
«The way I think
of radiation is it's like building a brick wall,» said
study co-lead author Dr. Nicholas G. Zaorsky, a radiation oncologist and assistant professor
of radiation oncology at Penn State College
of Medicine.
Javey worked with
study co-lead authors Wei Gao and Sam Emaminejad, both
of whom are postdoctoral fellows in his lab.
«As a result
of the
study we can now more precisely regulate — and increase — muscle mass in the setting
of disease,»
co-lead author from Monash BDI, Dr Craig Harrison, said.
To address this, Staley and Joseph Piccirilli, PhD, professor
of biochemistry and molecular biology and chemistry at the University
of Chicago, partnered with graduate students Sebastian Fica and Nicole Tuttle,
co-lead authors on the
study.