Not exact matches
«We are in the process
of elucidating the exact mechanism by which B2M
works,» said Saul A. Villeda, PhD, a UCSF Faculty Fellow and
co-senior author of the new study.
«Our
work strongly supports that cancer stem cells are the main source
of growth in these tumors and, as such, should be considered promising targets for treatment,» says Mario Suvà, MD, PhD,
of the MGH Department
of Pathology,
co-senior author of the Nature paper.
«For someone like myself, in this kind
of work, this is the kind
of result that you get to see once in your career,» said study
co-senior author Philippe Armand, MD, PhD, medical oncologist in the Hematologic Oncology Treatment Center at Dana - Farber.
Based on that assumption, many companies tested PKC inhibitors as drugs to treat cancer, but they didn't
work,» said
co-senior author Alexandra Newton, PhD, professor
of pharmacology at UC San Diego School
of Medicine.
Working together was critical to reaching that goal,» said study
co-senior author Bronwyn MacInnis, associate director
of malaria and viral genomics in the Broad's Infectious Disease and Microbiome Program.
«The biochemical mechanisms
of these proteins have been known for years from experiments involving purified protein and DNA, and that's very important, but in this new
work we've clarified these proteins» roles in living cells,» said
co-senior author Christopher P. Selby, PhD, research assistant professor
of biochemistry and biophysics at UNC.
«The results position TRPV4 as a new target for preventing and treating sunburn, and probably chronic sun damage including skin cancer or skin photo - aging, though more
work must be done before TRPV4 inhibitors can become part
of the sun defense arsenal, perhaps in new kinds
of skin cream, or to treat chronic sun damage,» said Steinhoff,
co-senior author of the study.
«The majority
of cancer patients we
work with are excited to participate in clinical trials that could benefit future patient outcomes down the line,» says
co-senior author Bryan Allen, who led the clinical side
of the study.
I didn't believe her,» said
co-senior author, Tom Lane, Ph.D., a professor
of pathology at the University
of Utah, who began the
work at University
of California, Irvine.
The electron microscopy
work was a collaboration with Elizabeth Wright, PhD, Emory associate professor
of pediatrics and
co-senior author on the paper, and her colleagues at Emory's Robert P. Apkarian Integrated Electron Microscopy Core.
In this new
work,
co-senior author Xiao Zhen Zhou, MD, an investigator in BIDMC's Division
of Translational Therapeutics and Assistant Professor at Harvard Medical School, decided to take a different approach to identify Pin1 inhibitors: She developed a mechanism - based high throughput screen to identify compounds that were targeting active Pin1.
But Markovitz and his
co-senior author Hashim M. Al - Hashimi, Ph.D., professor
of biochemistry at Duke University and formerly professor
of chemistry and biophysics at U-M, hope that their team's
work can help address the lack
of antiviral drugs that
work well against many viruses or against viruses that change rapidly, such as influenza.
«Tobacco was used as the model crop plant in this study because it is easy to
work with, but we're
working to make the same modifications in rice and other food crops,» said
co-senior author Krishna Niyogi, a faculty scientist in Berkeley Lab's Division
of Molecular Biophysics and Integrative Bioimaging.
«Our study reveals a spectrum
of methods that nature uses to allow organisms to adapt to different environments,» said
co-senior author Kerstin Lindblad - Toh, Co-Director
of SciLifeLab, scientific director
of vertebrate genome biology at the Broad Institute and professor in comparative genomics at Uppsala University «These mechanisms are likely also at
work in humans and other vertebrates, and by focusing on the remarkably diverse cichlid fishes, we were able to study this process on a broad scale for the first time.»