The electron microscopy work was a collaboration with Elizabeth Wright, PhD, Emory associate professor of pediatrics and
co-senior author on the paper, and her colleagues at Emory's Robert P. Apkarian Integrated Electron Microscopy Core.
Molong Li, Mark White, Lei Liu, and Daniel He also contributed to the research, and Katherine Pollard and Benoit Bruneau from the Gladstone Institutes were
co-senior authors on the paper.
Not exact matches
We wanted to understand what types of differences are always there, what is causing them, and what they mean,» says Juan Carlos Izpisua Belmonte, a professor in Salk's Gene Expression Laboratory and
co-senior author, with Kelly Frazer of the University of California, San Diego,
on the new
paper, which was published in Cell Stem Cell in April 2017.
«Healthy gut bacterial communities are known to benefit immune regulation, metabolism and potentially even the nervous system, so if cholera or other diarrheal diseases permanently impact the microbiota, there could be long - term effects
on human health,» explains Regina LaRocque, MD, MPH, of the Massachusetts General Hospital (MGH) Division of Infectious Diseases,
co-senior author of the
paper.
«Fascinating genetic studies had been done
on SMCHD1 that linked the gene to FSHD2, a rare muscular dystrophy involving the interaction of multiple genetic sites, but it had never been connected to craniofacial abnormalities,» says Michael Talkowski, PhD, of the MGH Center for Human Genetic Research,
co-senior author of the Nature Genetics
paper.
«This
paper is a great example of how chemistry can help make step changes in biology,» says Matthew Dalby, a professor of cell engineering at the University of Glasgow and
co-senior author on the study with Ulijn.
Joslin's Salvatore Iovino and Alison Burkart were co-lead
authors on the
paper, and Joslin's Mary - Elizabeth Patti, MD, was
co-senior author.
But Brian Shoichet,
co-senior author on the Nature
paper and professor in the department of pharmaceutical chemistry at the University of California, San Francisco, says that they had another requirement, too, which was met by only a tiny subset of those molecules.
«A huge fraction of the human «proteome» remains uncharacterized, and this
paper shows how chemical approaches can be used to uncover proteins of a given functionality that have eluded classification based
on sequence or predicted structure,» said
co-senior author Benjamin F. Cravatt, chair of TSRI's Department of Chemical Physiology.
«The ultimate goal in treating heart failure is a robust, reliable way for the heart to create new muscle cells,» said Srivastava,
co-senior author on the Science
paper.