Instead, we gave it a vehicle to travel in, making it better capable of navigating the terrain inside the inner ear and accessing previously resistant cells,» said Maguire, who is also
co-senior author on the study.
Sheng Ding, PhD, a senior investigator in the Roddenberry Stem Cell Center at Gladstone and
co-senior author on the study, adds, «This new cellular reprogramming and expansion paradigm is more sustainable and scalable than previous methods.
«Our results demonstrate for the first time that human adult skin cells can be used to efficiently and rapidly generate functional pancreatic cells that behave similar to human beta cells,» says Matthias Hebrok, PhD, director of the Diabetes Center at UCSF and
a co-senior author on the study.
«This paper is a great example of how chemistry can help make step changes in biology,» says Matthew Dalby, a professor of cell engineering at the University of Glasgow and
co-senior author on the study with Ulijn.
George Hajishengallis, Thomas W. Evans Centennial Professor in Penn's School of Dental Medicine's Department of Biology, and John D. Lambris, Dr. Ralph and Sallie Weaver Professor of Research Medicine in the Perelman School of Medicine's Department of Pathology and Laboratory Medicine, were
co-senior authors on the study, the result of years of collaboration.
«The methods for achieving transplantation tolerance differ between mice and humans, but the mechanisms that maintain it are likely shared,» said Marisa Alegre, MD, PhD, professor of medicine at the University of Chicago and
co-senior author on the study.
Khalil served as
co-senior author on the study with Radhika Atit, PhD, professor of biology at Case Western Reserve University School of Medicine.
«We undertook this study to understand the consequences of Zika virus infection in males,» said Michael Diamond, MD, PhD,
a co-senior author on the study and the Herbert S. Gasser Professor of Medicine.
Not exact matches
«Fascinating genetic
studies had been done
on SMCHD1 that linked the gene to FSHD2, a rare muscular dystrophy involving the interaction of multiple genetic sites, but it had never been connected to craniofacial abnormalities,» says Michael Talkowski, PhD, of the MGH Center for Human Genetic Research,
co-senior author of the Nature Genetics paper.
Professor Gary Blissard of the Boyce Thompson Institute at Cornell University, and Professor Michael Kanost of Kansas State University, initiated the
study and are
co-senior authors on this large international project that included 114 researchers from 50 institutions and 11 countries.
Boehme conducted the
study with fellow University of Utah physicists: first
author and postdoctoral fellow Hans Malissa; research professor and
co-senior author John Lupton, who also is
on the faculty of the University of Regensburg, Germany; distinguished professor Z. Valy Vardeny; professor Brian Saam; graduate students Marzieh Kavand and David Waters; and postdoctoral fellow Kipp van Schooten.
«Genomics is
on the verge of transforming the healthcare system — this
study highlights the potential clinical benefits that can be gained through genomic
studies and offers potential strategies to improve patient care and disease management,» says Dr David Adams,
co-senior author from the Wellcome Trust Sanger Institute.
«Of note, the ACL - injured NFL athletes did not fair quite as well,» said Carey, who is also
co-senior author on the current
study.
«TWEAK and its signaling receptor, Fn14, have emerged as a fundamental molecular pathway regulating tissue responses after acute tissue injury and in many different contexts of chronic injury and disease» said Linda Burkly, Ph.D., Senior Distinguished Investigator, VP, Biogen, Inc., and
co-senior author on the current
study.
«This is the first systematic comparison of the mouse and human at the genomic level,» said Bing Ren, Ph.D.,
co-senior author on the Consortium's main Nature
study and professor of cellular and molecular medicine at the University of California, San Diego.
«This is a significant example of how knowing details of potential mechanisms and the basic science of redox active compounds in cancer versus normal cells can be leveraged clinically in cancer therapy,» says
co-senior author Douglas Spitz, who focused
on the biochemical
studies.
Co-senior author on the Cancer Cell
study, Dr. Matthew Wilkerson, associate professor and Bioinformatics Director of The American Genome Center and the Collaborative Health Initiative Research Program at the Uniformed Services University.
«These data suggest that the interplay between race and ethnicity as social constructs and genetic ancestry as a biological construct is more complex than we had realized,» said Noah Zaitlen, PhD, a UCSF assistant professor of medicine and
co-senior author on the new
study.
«Our
study reveals a spectrum of methods that nature uses to allow organisms to adapt to different environments,» said
co-senior author Kerstin Lindblad - Toh, Co-Director of SciLifeLab, scientific director of vertebrate genome biology at the Broad Institute and professor in comparative genomics at Uppsala University «These mechanisms are likely also at work in humans and other vertebrates, and by focusing
on the remarkably diverse cichlid fishes, we were able to
study this process
on a broad scale for the first time.»