Sentences with word «coactivator»

These differences suggest that adapting to exercise involves many processes, but scientists have observed that one gene in particular, peroxisome proliferator - activated receptor - gamma coactivator PGC - 1α, controls many of them.

The expression of mRNA for factors involved in promoting mitochondrial biogenesis, including the transcription factor Ppard, the PPARδ coactivator Pgc - 1α, and citrate synthase was greater in gastrocnemius muscles from IL - 15Rα — KO relative to B6129 control (Figure 5C); however, levels of these genes were unchanged in spleen and kidney (data not shown).

It is a required coactivator of TGF - beta, Notch and nuclear receptor genes.

Dissection of the LXXLL nuclear receptor - coactivator interaction motif using combinatorial peptide libraries: discovery of peptide antagonists of estrogen receptors alpha and beta

(In more technical terms, vitamin A is said to «recruit coactivators» that are needed for expression of vitamin D receptors, and the form of vitamin A needed to assist with vitamin D metabolism in this situation is 9 - cis - retinoic acid.)

Among transcripts that were decreased in ABL1 / ABL2 knockdown cells were TAZ [also known as WWTR1 (WW domain — containing transcription regulator protein 1)-RSB-, which encodes a transcriptional coactivator in the Hippo pathway, and STAT5A, which encodes a transcription factor (Fig. 6C).

Among the other genes she says play a role in thoroughbred performance are peroxisome proliferator - activated receptor - γ coactivator - 1 alpha (PGC - 1α), which is involved in skeletal muscle adaptation to exercise; pyruvate dehydrogenase kinase, isozyme 4 (PDK4), involved in glucose regulation, expression of which increased almost fourfold after sprints; and cytochrome c oxidase subunit 4 isoform 2 (COX 4I2), involved in respiration.

PAD4 targets multiple sites in histones H3 and H4, including those sites methylated by coactivators CARM1 (H3 Arg17) and PRMT1 (H4 Arg3).

Reference: Immunity, «The PIAS - like coactivator Zmiz1 is a direct and selective cofactor of Nortch1 in T - cell development and leukemia,» published online Oct. 27

The findings in a recent issue of Cell demonstrate how PGC - 1a1, a transcriptional coactivator induced in skeletal muscle by exercise and endurance, protects the brain from depression.

However, it is unclear whether this enhanced interaction selectively facilitates transcription of specific p53 target genes, including sestrins, or whether p53 serine18 phosphorylation also regulates specific target genes by altering interactions of p53 with other coactivators such as chromatin modifying enzymes.

Our preliminary data have shown that p53 directly interacts with a component (MED17) of the multi-subunit Mediator coactivator complex, which is an essential part of the general transcription machinery, and that serine18 phosphorylation enhances this interaction.

The team found that in ES cells attempting to differentiate prematurely, Nanog actually binds to Smad1 protein and interferes with its ability to recruit those obligatory coactivators, thereby rendering Smad1 powerless to initiate muscle gene expression.

Transcriptional coactivator for steroid receptors and nuclear receptors.

In breast cancer cells, the ABL kinases activated the transcriptional coactivator TAZ and the transcription factor STAT5, which triggered the transcription of genes encoding factors that activate osteoclasts (cells that break down bone) and those that enhance the survival of breast cancer cells in the bone microenvironment.

UT Southwestern biochemists studying mouse models found that the two proteins − steroid receptor coactivators 1 and 2 (SRC - 1 and SRC - 2)-- control genes for pulmonary surfactant components that promote the initiation of labor.

FNDC5 expression was shown to correlate with peroxisome proliferator - activated receptor gamma coactivator 1 - alpha (PGC - 1α) expression levels in various developmental stages and tissues, including neurons.

Analyses of virus - induced homomeric and heteromeric protein associations between IRF - 3 and coactivator CBP / p300.

In parallel, we will investigate the accumulation and function of transcription coactivators, including the Mediator and different histone modifying enzymes, on endogenous sestrin genes in mouse cells expressing wild type versus serine18 mutant p53.

First, we will use our unique DNA - and chromatin - templated in vitro transcription systems to investigate the direct role of p53 serine18 phosphorylation in sestrin gene activation through modulation of p53 - coactivator interactions.

Activation seems to require recruitment of transcriptional coactivators such as CREBPB and probably EP300.

p53 is stabilized and activated in response to a variety of stress signals and, in turn, activates specific target genes through its function as a conventional transcription factor that binds to specific promoter sites and interacts with various transcriptional coactivators.

GT198, which is also a coactivator of receptors for steroid hormones such as estrogen, is normally regulated by estrogen, Ko said.

The therapy consists in injecting into the hippocampus - a region of the brain essential to memory processing - a gene which causes the production of a protein blocked in patients with Alzheimer's, the «Crtc1» (CREB regulated transcription coactivator - 1).

Members of the steroid receptor coactivator (SRC) family of oncogenes are especially promising as therapeutic targets because these proteins sit at the nexus of key signaling pathways that cancer cells use to quickly grow, spread to other tissues, and acquire drug resistance.

Steroid receptor coactivators 1 and 2 mediate fetal - to - maternal signaling that initiates parturition.

In addition to prevent ROS mediated damages SIRT1 promotes mitochondrial biogenesis by activating peroxisome proliferator - activated receptor coactivator - 1α (PGC - 1α) which upregulates glutathione peroxidase (GPx1), catalase, and manganese SOD (MnSOD) 22.

Li J, Zhao Z, Carter C, Ehrlich LI, Bedford MT, Richie ER (2013) Coactivator - Associated Arginine Methyltransferase 1 Regulates Fetal Hematopoiesis and Thymocyte Development.

We hypothesized that the MfR subunits, methoprene - tolerant transcription factor (Met) and steroid receptor coactivator (SRC), would be expressed coincident with the timing of sex programming of developing oocytes by methyl farnesoate in daphnids.

Distribution and sexually dimorphic expression of steroid receptor coactivator - 1 (SRC - 1) in the zebra finch brain.

The song remains the same: coactivators and sex differences in the songbird brain.

Peroxisome proliferator activated receptor gamma coactivator 1 alpha transcript variant B4 antibody

Peroxisome proliferator activated receptor gamma coactivator 1 alpha transcript variant B4 3ext antibody

Interferon --LCB- gamma -RCB-- activated STAT - 1 -LCB- alpha -RCB- suppresses MMP - 9 gene transcription by sequestration of the coactivators CBP / p300

Peroxisome proliferator activated receptor gamma coactivator 1 alpha transcript variant B4 8a antibody

Peroxisome proliferator activated receptor gamma coactivator 1 alpha transcript variant B5 NT antibody

Coactivator - Dependent Oscillation of Chromatin Accessibility Dictates Circadian Gene Amplitude through REV - ERB Loading.

When fastening to the PPAR receptor, it was discovered that Cardarine recruits the coactivator PGC - 1 a enzyme that increases genes appearance in the energy expenditure.

Exercise activation of muscle peroxisome proliferator - activated receptor - gamma coactivator - 1alpha signaling is redox sensitive.