Sentences with phrase «coactivator in»

Among transcripts that were decreased in ABL1 / ABL2 knockdown cells were TAZ [also known as WWTR1 (WW domain — containing transcription regulator protein 1)-RSB-, which encodes a transcriptional coactivator in the Hippo pathway, and STAT5A, which encodes a transcription factor (Fig. 6C).

Not exact matches

These differences suggest that adapting to exercise involves many processes, but scientists have observed that one gene in particular, peroxisome proliferator - activated receptor - gamma coactivator PGC - 1α, controls many of them.

The therapy consists in injecting into the hippocampus - a region of the brain essential to memory processing - a gene which causes the production of a protein blocked in patients with Alzheimer's, the «Crtc1» (CREB regulated transcription coactivator - 1).

Among the other genes she says play a role in thoroughbred performance are peroxisome proliferator - activated receptor - γ coactivator - 1 alpha (PGC - 1α), which is involved in skeletal muscle adaptation to exercise; pyruvate dehydrogenase kinase, isozyme 4 (PDK4), involved in glucose regulation, expression of which increased almost fourfold after sprints; and cytochrome c oxidase subunit 4 isoform 2 (COX 4I2), involved in respiration.

PAD4 targets multiple sites in histones H3 and H4, including those sites methylated by coactivators CARM1 (H3 Arg17) and PRMT1 (H4 Arg3).

The expression of mRNA for factors involved in promoting mitochondrial biogenesis, including the transcription factor Ppard, the PPARδ coactivator Pgc - 1α, and citrate synthase was greater in gastrocnemius muscles from IL - 15Rα — KO relative to B6129 control (Figure 5C); however, levels of these genes were unchanged in spleen and kidney (data not shown).

Reference: Immunity, «The PIAS - like coactivator Zmiz1 is a direct and selective cofactor of Nortch1 in T - cell development and leukemia,» published online Oct. 27

The findings in a recent issue of Cell demonstrate how PGC - 1a1, a transcriptional coactivator induced in skeletal muscle by exercise and endurance, protects the brain from depression.

The song remains the same: coactivators and sex differences in the songbird brain.

FNDC5 expression was shown to correlate with peroxisome proliferator - activated receptor gamma coactivator 1 - alpha (PGC - 1α) expression levels in various developmental stages and tissues, including neurons.

First, we will use our unique DNA - and chromatin - templated in vitro transcription systems to investigate the direct role of p53 serine18 phosphorylation in sestrin gene activation through modulation of p53 - coactivator interactions.

In summary, our study in human NSCLC cells demonstrates that unphosphorylated STAT6 contributes to constitutive COX - 2 transcription via binding to the COX - 2 promoter in association with transcription coactivator p30In summary, our study in human NSCLC cells demonstrates that unphosphorylated STAT6 contributes to constitutive COX - 2 transcription via binding to the COX - 2 promoter in association with transcription coactivator p30in human NSCLC cells demonstrates that unphosphorylated STAT6 contributes to constitutive COX - 2 transcription via binding to the COX - 2 promoter in association with transcription coactivator p30in association with transcription coactivator p300.

Their gene expression profile revealed striking up - regulation of peroxisome proliferator - activated receptor gamma coactivator 1alpha (an up - regulator of mitochondrial biogenesis not normally expressed in white fat), increased uncoupling proteins - 1 and -2, and down - regulation of lipogenic enzymes.

In breast cancer cells, the ABL kinases activated the transcriptional coactivator TAZ and the transcription factor STAT5, which triggered the transcription of genes encoding factors that activate osteoclasts (cells that break down bone) and those that enhance the survival of breast cancer cells in the bone microenvironmenIn breast cancer cells, the ABL kinases activated the transcriptional coactivator TAZ and the transcription factor STAT5, which triggered the transcription of genes encoding factors that activate osteoclasts (cells that break down bone) and those that enhance the survival of breast cancer cells in the bone microenvironmenin the bone microenvironment.

(In more technical terms, vitamin A is said to «recruit coactivators» that are needed for expression of vitamin D receptors, and the form of vitamin A needed to assist with vitamin D metabolism in this situation is 9 - cis - retinoic acidIn more technical terms, vitamin A is said to «recruit coactivators» that are needed for expression of vitamin D receptors, and the form of vitamin A needed to assist with vitamin D metabolism in this situation is 9 - cis - retinoic acidin this situation is 9 - cis - retinoic acid.)

When fastening to the PPAR receptor, it was discovered that Cardarine recruits the coactivator PGC - 1 a enzyme that increases genes appearance in the energy expenditure.