Sentences with phrase «coactivator of»

It is a required coactivator of TGF - beta, Notch and nuclear receptor genes.

GT198, which is also a coactivator of receptors for steroid hormones such as estrogen, is normally regulated by estrogen, Ko said.

Not exact matches

UT Southwestern biochemists studying mouse models found that the two proteins − steroid receptor coactivators 1 and 2 (SRC - 1 and SRC - 2)-- control genes for pulmonary surfactant components that promote the initiation of labor.

These differences suggest that adapting to exercise involves many processes, but scientists have observed that one gene in particular, peroxisome proliferator - activated receptor - gamma coactivator PGC - 1α, controls many of them.

The therapy consists in injecting into the hippocampus - a region of the brain essential to memory processing - a gene which causes the production of a protein blocked in patients with Alzheimer's, the «Crtc1» (CREB regulated transcription coactivator - 1).

Among the other genes she says play a role in thoroughbred performance are peroxisome proliferator - activated receptor - γ coactivator - 1 alpha (PGC - 1α), which is involved in skeletal muscle adaptation to exercise; pyruvate dehydrogenase kinase, isozyme 4 (PDK4), involved in glucose regulation, expression of which increased almost fourfold after sprints; and cytochrome c oxidase subunit 4 isoform 2 (COX 4I2), involved in respiration.

The expression of mRNA for factors involved in promoting mitochondrial biogenesis, including the transcription factor Ppard, the PPARδ coactivator Pgc - 1α, and citrate synthase was greater in gastrocnemius muscles from IL - 15Rα — KO relative to B6129 control (Figure 5C); however, levels of these genes were unchanged in spleen and kidney (data not shown).

Reference: Immunity, «The PIAS - like coactivator Zmiz1 is a direct and selective cofactor of Nortch1 in T - cell development and leukemia,» published online Oct. 27

Analyses of virus - induced homomeric and heteromeric protein associations between IRF - 3 and coactivator CBP / p300.

The findings in a recent issue of Cell demonstrate how PGC - 1a1, a transcriptional coactivator induced in skeletal muscle by exercise and endurance, protects the brain from depression.

Unlike previously described mutations causing dilated cardiomyopathy that affect structural proteins, this mutation deletes 4,846 bp of the human transcriptional coactivator gene EYA4.

However, it is unclear whether this enhanced interaction selectively facilitates transcription of specific p53 target genes, including sestrins, or whether p53 serine18 phosphorylation also regulates specific target genes by altering interactions of p53 with other coactivators such as chromatin modifying enzymes.

First, we will use our unique DNA - and chromatin - templated in vitro transcription systems to investigate the direct role of p53 serine18 phosphorylation in sestrin gene activation through modulation of p53 - coactivator interactions.

Their gene expression profile revealed striking up - regulation of peroxisome proliferator - activated receptor gamma coactivator 1alpha (an up - regulator of mitochondrial biogenesis not normally expressed in white fat), increased uncoupling proteins - 1 and -2, and down - regulation of lipogenic enzymes.

Dissection of the LXXLL nuclear receptor - coactivator interaction motif using combinatorial peptide libraries: discovery of peptide antagonists of estrogen receptors alpha and beta

Interferon --LCB- gamma -RCB-- activated STAT - 1 -LCB- alpha -RCB- suppresses MMP - 9 gene transcription by sequestration of the coactivators CBP / p300

In breast cancer cells, the ABL kinases activated the transcriptional coactivator TAZ and the transcription factor STAT5, which triggered the transcription of genes encoding factors that activate osteoclasts (cells that break down bone) and those that enhance the survival of breast cancer cells in the bone microenvironment.

Coactivator - Dependent Oscillation of Chromatin Accessibility Dictates Circadian Gene Amplitude through REV - ERB Loading.

(In more technical terms, vitamin A is said to «recruit coactivators» that are needed for expression of vitamin D receptors, and the form of vitamin A needed to assist with vitamin D metabolism in this situation is 9 - cis - retinoic acid.)