Not exact matches
Porous metal implants that were
coated with the
microspheres prevented infection in 100 percent of the 11 specimens.
Each
microsphere is
coated with collagen — a natural structural material — to provide a surface on which the stem and blood cells can anchor themselves and proliferate.
When DNA was added, it bound only to the hills, turning them into regions that could bind to
microspheres coated in complementary DNA.
Next, they filled in the gaps between the
microspheres with liquid styrene, which was not
coated in the DNA binder.
For their atoms, the team used polystyrene
microspheres — either 540 or 850 nanometres across, more than 2000 times bigger than real atoms —
coated in a substance that binds to DNA.
By
coating the implant in the antibiotic
microspheres before placing it in the patient's joint, the antibiotics are delivered directly to the surgical site to help prevent bacteria from developing into an infection.
In studies to determine the efficacy of the
microspheres, Clyburn and his team contaminated two metal implants with staphylococcus aureus bacteria and
coated one in the
microspheres before inserting them in animal models.