These «organs on a chip,» as they are called, are typically glass slides
coated with human cells that have been configured to mimic a particular tissue or interface between tissues.
Not exact matches
The researchers have
coated DNA nanostructures
with virus capsid proteins in order to significantly improve their transport to
human cells; this could find uses for example in enhanced drug delivery.
In the second study in Science, researchers from Harvard University in Boston, Massachusetts, created a chip 1 to 2 centimeters long in which a 1 millimeter - wide channel,
coated with human lung
cells on the inside and overlaid
with human blood capillaries on the outside, mimicked the air sacs, or alveoli, of the lungs.
The epithelium's maturation into a villus intestinal epithelium
with long finger - like extensions was helped along by co-culturing
human intestinal microvascular endothelial
cells on the opposite side of the shared matrix -
coated porous membrane in the «vascular» channel where they assembled a surrogate blood vessel
with a hollow lumen through which feeding medium was flowed.
In one well - studied example, the bacteria called Campylobacter jejuni, a common cause of food poisoning, carries a lipid molecule on its outer
coat that resembles so - called gangliosides, molecules that help
human nerve
cells recognize and communicate
with each other.
Despite the ability of R3A to utilize both CCR5 and CXCR4 to infect
cell lines, in
human CD4 + T
cells stimulated
with anti-CD3 / anti-CD28
coated magnetic beads, CCR5 is downregulated causing transient resistance to R5 HIV [47].
HAT sensitive derivative of CEM, a
human T -
cell line derived from the peripheral blood buffy
coat of a four - year old Caucasian female
with acute lymphoblastic leaukemia.
Coating Human Pancreatic Islets
With CD4 + CD25highCD127 - Regulatory T
Cells as a Novel Approach for the Local Immunoprotection.
The membrane is
coated with proteins that support 3 - D
cell growth and it's seeded
with human intestinal epithelial
cells (from a
cell line originally isolated from a colon cancer).