Demonstration of low serum
cobalamin is the more useful finding, since it is less influenced by diet and coprophagia and
appears to relate more to the severity of clinical disease
Cats
appear highly susceptible to
cobalamin deficiency, partly as a result of the very rapid turnover of this vitamin compared with humans.49 Cats with decreased serum
cobalamin concentrations should be supplemented with subcutaneously administered
cobalamin at a dose of 1000 μg per cat once weekly for 6 weeks, with reassessment of the serum
cobalamin concentration approximately one month after discontinuing therapy.