Similar studies in cats have shown that most, if not all, cats needing pancreatic enzyme supplementation would benefit from
cobalamin supplementation.»
Toresson L, Steiner JM, Suchodolski JS, Spillman T. Oral
cobalamin supplementation in dogs with chronic enteropathies and hypocobalaminemia.
(2005), Early Biochemical and Clinical Responses to
Cobalamin Supplementation in Cats with Signs of Gastrointestinal Disease and Severe Hypocobalaminemia.
Therefore, parenteral
cobalamin supplementation should be considered when hypocobalaminemia is documented.»
Very little evidence - based information about
cobalamin supplementation in dogs and cats is available.
Managing exocrine pancreatic insufficiency involves a five - pronged approach that includes supplementation with digestive enzymes missing from the dog's pancreas, feeding the dog 150 percent of her usual rations, treatment for bacterial overgrowth in the gut that results from the disease,
cobalamin supplementation, and a low - fiber diet.
However, the benefit of
cobalamin supplementation in normocobalaminemic cats with EPI warrants further investigation.
Cobalamin supplementation favorably affected response to treatment.
Cobalamin supplementation had a positive impact on treatment response, potentially even in cases that had serum cobalamin concentrations within the reference interval.
It is not clear why
cobalamin supplementation may have a positive effect on hypocobalaminemic cats with EPI, but these cats may have depleted tissue cobalamin concentrations before hypocobalaminemia develops.
This observation is not surprising because most cats were hypocobalaminemic, and
cobalamin supplementation has been shown to be beneficial in hypocobalaminemic cats with gastrointestinal disease.
Most cats respond well to appropriate treatment for EPI, and
cobalamin supplementation appears to be necessary for a good response.
The authors recommend a larger, prospective study to further evaluate the benefits of oral
cobalamin supplementation compared to administration via injection.
This retrospective study provides preliminary evidence that oral
cobalamin supplementation is likely to be a successful alternative to parenteral administration.
The objective of a Winn Feline Foundation funded study was to evaluate whether oral
cobalamin supplementation in cats would provide the same benefits as parenteral supplementation.
Not exact matches
Those with elevated homocysteine should begin prompt
supplementation with a trio of B vitamins — folate, vitamin B6 (pyridoxine) and vitamin B12 (
cobalamin)-- which can successfully reduce homocysteine via the body's natural detoxification pathways.
Supplementation is best using a B - complex that contains the Methyl - folate (not folic acid) and B 12 Methyl
cobalamin forms.
Cats with EPI will at least require dietary
supplementation with pancreatic enzymes for resolution of clinical signs, and additional treatment with parenteral
cobalamin is necessary in many cases.
Vitamin
Supplementation Serum concentrations of
cobalamin (vitamin B12) and vitamin E are often subnormal in dogs with EPI and do not necessarily increase in response to treatment with enzymes, even though the clinical response may otherwise be excellent.
Patients that do not respond to therapy Some dogs and cats do not respond to enzyme
supplementation and
cobalamin application.
Recent evidence from studies at the Gastrointestinal Laboratory have also shown that
supplementation of
cobalamin is important to get the best response to therapy for gastrointestinal disease.
Cobalamin deficiency is associated with anemia and neuropathy; and even pets on
supplementation enzymes may require ongoing B12 injections.
Cobalamin (vitamin B12) and folate (vitamin B9)
supplementation is also required where bacteria have depleted the normal sources of these important vitamins.