So the natural extension of this paper's line of inquiry is how the positive and negative systems associated with
cocaine use change when animals are exposed to multiple doses in any given day (i.e. addiction).
Not exact matches
Researchers at the University at Buffalo have discovered a previously unknown neural pathway that can regulate
changes made in the brain due to
cocaine use, providing new insight into the molecular basis of
cocaine addiction.
With the combined
use of genetics and pharmacology, the investigators altered the production of proteins controlled by eIF2α in adult mice, essentially converting them into adolescents by making them more susceptible to
cocaine - induced
changes in synaptic strength and behavior.
The George lab has made seminal contributions to the field including: discovering a novel population of neurons in the brain of humans, rats and mice that are involved in nicotine dependence, identifying neuronal ensembles responsible for nicotine and alcohol addiction, and unveiled the cellular and molecular
changes associates with long term
use of nicotine,
cocaine, methamphetamine and alcohol
use on the brain.
In a similar medical experiment, researchers discovered that
cocaine -
using mice passed memory problems on to three generations of descendants thanks to epigenetic
changes.
But while the researchers found little
change from last year in most drug categories, they noted a disturbing increase in the
use of several dangerous drugs, particularly
cocaine.