Cochlear hair cells normally detect positive deflections of their hair bundles, rotating toward their tallest edge, which opens mechanotransducer (MT) channels by increased tension in interciliary tip links.
Selective deletion of
cochlear hair cells causes rapid age - dependent changes in spiral ganglion and cochlear nucleus neurons.
The device was tested in a guinea pig, with the electrodes attached to both sides of the rodent's
cochlear hair cell membranes.
The best association was found at chromosome 3 close to the GATA2 gene that regulates the development of
cochlear hair cells and the inferior colliculus (IC) in the auditory pathway.
Loud sounds put too much pressure on
the cochlear hair cells, which can damage or kill them.
After exposing supporting cells — cells that can create new
cochlear hairs — to a specialized drug mixture, the team saw significant new hair cell growth.
They thought that a low hum might straighten out those bent
cochlear hairs.
Not exact matches
Using lasers instead of electrodes to vibrate the
hairs in the inner ears could lead to less damaging
cochlear implants
As the cochlea's fluid moves, about 15,000
hair cells sitting in it, each tuned to a particular frequency, pick up the motions; the
cochlear nerve translates the movements into auditory messages that are sent to the brain.
«But we already have
cochlear implants to replace
hair cells, so we decided the first priority was to start by targeting the neurons.»
Treatment has focused on electronic devices like hearing aids or
cochlear implants because once lost, human auditory
hair cells do not grow back.
Cochlear (inner ear) development occurs normally to that point, but the blood supply to the cochlea (the stria vascularis) degenerates, so the
hair cells of the cochlea die.