Hearing Hairs Restored: Tiny hairs in our inner ears,
called cochlear hair cells, are vital to our natural perception of sound, and once we lose them, we don't grow them back.
Cochlear hair cells normally detect positive deflections of their hair bundles, rotating toward their tallest edge, which opens mechanotransducer (MT) channels by increased tension in interciliary tip links.
The «reverse - polarity» current was investigated
in cochlear hair cells after tip - link destruction with BAPTA, in transmembrane channel - like protein isoforms 1/2 (Tmc1: Tmc2) double mutants, and during perinatal development.
Recent studies have shown that deafness in Dobermans, which do not carry the merle or piebald genes, results from direct loss of
cochlear hair cells without any effects on the stria vascularis.
The best association was found at chromosome 3 close to the GATA2 gene that regulates the development
of cochlear hair cells and the inferior colliculus (IC) in the auditory pathway.
Loud sounds put too much pressure on
the cochlear hair cells, which can damage or kill them.