Not exact matches
The study results revolve around the relationship between TET2 and
cytosine, one of the four nucleic acid «letters» that comprise the DNA
code in genes.
The sequence GGAC,
code for the bases guanine - guanine - adenine -
cytosine, stood out because it appeared with surprising frequency in the unprocessed primary microRNAs.
Sequencing devices take long strings of a person's DNA and randomly chop them into small pieces that can be individually analyzed to determine their sequence of letters from the genetic
code (A, C, G and T representing the four key components of DNA that
code for protein production in living organisms: adenine,
cytosine, guanine and thymine).
The tests look for differences in the DNA nucleotides adenosine, thymine, guanine, and
cytosine (A, T, G, and C — the letters of the genetic
code) between one person and another, or between one group of people and another group.
The researchers analyzed hundreds of human transcription factors, which are proteins that read the genetic information
coded in DNA's sequence of four nucleotide bases — adenine (A),
cytosine (C), guanine (G) and thymine (T)-- and pass that on to RNA molecules.
These
coding regions of the genome have a characteristic broad distribution of GC3 (fraction of
cytosine and guanine in the third position of a codon) with over half the GC3 - rich genes (GC3.
With four different nucleotides comprising our genetic
code (adenine, guanine,
cytosine, and thymine), the barcodes are long enough to be distinct from other stretches of DNA in the genome, and also allow for the generation of a seemingly limitless number of
codes.