Most RNA molecules do
not code for protein, but instead perform regulatory functions, such as determining the ways in which genes are expressed.
In the future, the researchers hope to expand their analysis, using SDSC's Comet supercomputer, from 10,000 protein families to one million individual genes, each of
which codes for a protein which can be expressed in the gut microbiome.
The mealybug genome harbors 22 genes from bacteria with ancestors unrelated to Tremblaya and Moranella, but these genes, which
code for proteins involved in the production of essential nutrients and the synthesis of the cellular wall enclosing the bacteria, «fit with things missing in the symbionts,» said McCutcheon.
The new locus they have identified is near a cluster of genes which
code for proteins called «glycophorins» that are involved in the malaria parasite's invasion of red blood cells.
The beta - ARK cDNA
codes for a protein of 689 amino acids (79.7 kilodaltons) with a protein kinase catalytic domain that bears greatest sequence similarity to protein kinase C and the cyclic adenosine monophosphate (cyclic AMP)-- dependent protein kinase.
Researchers first injected monkeys with chains of
DNA coding for proteins from three strains of Ebola in order to develop immunity.
By splicing genes for the original protein with ones that
code for proteins containing different instructions, the researchers created a modified version of N - WASP.
Among mammals, the gene that
codes for the protein from which ß amyloid derives is «almost identical» across species, says Claudio Soto Jara, a neuroscientist at the University of Texas, Houston.
MicroRNAs are short bits of nucleic acid — the material of DNA and RNA — that can bind to messenger RNAs that
code for protein because they have a complementary sequence of A, U, C and G.
They found that the gene
codes for a protein known as CFTR which normally transports salt across cell membranes in the lungs, gut and sweat glands.
In essence, HLA - B * 57:01
codes for a protein on cell surfaces that hoists up little pieces of the virus, which, in turn, tell immune killer cells that this is an enemy that should be destroyed.
The team also carried out a so - called metagenomic analysis, in which the genomes from all organisms in a sample are sequenced collectively; the great majority of genes they
found coded for proteins never seen before.
For example, a 2003 study identified a mutation — a single - letter switch in the
genetic code for a protein called neuroligin - 3 — in two Swedish brothers, one with autism and one with the related but milder Asperger syndrome.
Because genes in the
brain code for proteins that interact with many other molecules, the wiggle room for evolutionary tinkering is limited: Change a gene too much and it will be unable to continue its existing functions.
A genetic analysis revealed the culprit to be a mutation in the gene SMARCAD1, specifically in a small portion that
codes for a protein only synthesized in the skin.
The team studied the genomes of almost 8,000 child and parent trios, focusing on genes that
coded for proteins as well as non-coding parts of the genome that control the switching on and off of genes, known as regulatory elements.
Interestingly, even though biologists long favored the view that viruses were mere boxes of chemicals, they took advantage of viral activity in host cells to determine how nucleic
acids code for proteins: indeed, modern molecular biology rests on a foundation of information gained through viruses.
SMCHD1 codes for a protein that regulates the expression of other genes and had previously been shown to contribute to FSHD2 (fascioscapulohumeral muscular dystrophy 2), a condition characterized by muscle weakness affecting the face, shoulders and upper arms.
They collected messenger RNA (mRNA), which is made from active genes and
eventually codes for proteins; because each gene has a unique corresponding mRNA strand, mRNA levels reveal which genes are actively making proteins.
The researchers have studied analyses of the genetic material of viruses found in newly infected people and, in particular, the gene env, which
codes for the protein envelope or «coat» around the virus.
Autophagy can be blocked in tumor cells and mouse models pharmacologically and genetically, the latter by inhibiting the expression of genes involved in the initiation of autophagy, for example
BECN1 coding for the protein Beclin - 1.
Indy codes for a protein that resembles a membrane protein found in many organisms, from bacteria to mammals, including humans.
«Our findings suggest that there may be a
universal code for protein sequence - structure relationships, written on the level of local structural fragments,» Grigoryan says.
According to a new study, a primitive protozoan called Giardia lamblia has at least one intron, a piece of «junk DNA» that exists in the middle of genes but doesn't
help code for a protein.
The disabled gene
codes for the protein PD - 1, which normally puts the brakes on a cell's immune response: cancers take advantage of that function to proliferate.
Sequencing devices take long strings of a person's DNA and randomly chop them into small pieces that can be individually analyzed to determine their sequence of letters from the genetic code (A, C, G and T representing the four key components of DNA that
code for protein production in living organisms: adenine, cytosine, guanine and thymine).
For many years, scientists have known that mutations in the genes
coding for the proteins BRCA1 and BRCA2 increase risk of breast and ovarian cancer by 30 % to 70 % and account for half of all hereditary cases of the diseases.
Earlier studies suggested that only, say, 3 to 15 percent of the genome had functional significance — that is, actually did something,
whether coding for proteins, regulating how the genes worked or doing something else.
They found that
EBB1 codes for a protein that helps to restart cell division in a part of the tree known as meristem, which is analogous to stem cells in animals.
A team of biologists led by Gerald Wilkinson of the University of Maryland, University Park, studied a type of Malaysian fly, called Cyrtodiopsis, with a strange genetic battle being waged inside its body: To perpetuate themselves, genes on the fly's X
chromosome code for proteins that kill sperm carrying a Y chromosome.
Perhaps most surprising is the discovery of a cluster of genes that
normally code for proteins used to form gas vesicles — typically used for buoyancy by water - living bacteria.
The group, led by genome scientist Yoshihide Hayashizaki, has developed techniques to count how frequently a gene is expressed — the process by which DNA is transcribed into RNA, which in
turn codes for a protein.
To test this hypothesis, an international team led by evolutionary biologist Gregory Wray of Duke University in Durham, North Carolina, focused on the gene that
codes for the protein prodynorphin (PDYN), a precursor to a number of endorphins, opiatelike molecules involved in learning, the experience of pain, and social attachment and bonding.
«Among the seven novel tumor suppressor genes we found, our strongest hit was Myh9, which
codes for the protein myosin IIa, a motor protein with well - known function in cell structure and cell migration,» says Schramek.
It also has extra genes that
code for proteins related to virus acquisition and transmission, as well as insecticide resistance.