Sentences with phrase «cognitive decline remain»

Not exact matches

Whole brain radiotherapy (WBRT) significantly improves tumor control in the brain after SRS, yet because of its association with cognitive decline, its role in the treatment of patients with brain metastases remains controversial.

The experiment revealed that, for reasons that remain unclear, the cholesterol - reducing treatment protects the heart in old age, although it doesn't guard against strokes or cognitive decline.

There is a finely graded inverse association between age and cognitive performance, 3 4 5 but the age at which cognitive decline becomes evident at the population level remains the subject of debate.5 6 7 A recent review of the literature concluded that there was little evidence of cognitive decline before the age of 60.8 This point of view, however, is not universally accepted.5 6 Clinicopathological studies show good correlation between neuropathology and the severity of cognitive decline, 9 10 11 and neurofibrillary tangles and amyloid plaques, the hallmarks of pathology, are known to be present in the brains of young adults.12 13 Emerging consensus on the long gestation period of dementia14 15 also suggests that adults aged under 60 are likely to experience age related cognitive decline.

This cognitive decline is not only due to the death of neurons, but also during aging there is a loss of neuronal connections called synapses, as well as a decline in function of the remaining synapses.

People with mild cognitive impairment that improves in the shorter term remain at increased risk of future cognitive decline

To date, the immediate and lasting positive effects of quality care on language, cognitive development, and school achievement have been confirmed by converging findings from large, reasonably representative longitudinal studies and smaller, randomized trials with long - term follow - ups.1, 2,9 - 13 Contributors to this knowledge base include meta - analytic reviews of interventions and large longitudinal studies conducted in several countries.1, 2,14,15 Comprehensive meta - analyses now establish that effects of early care decline, but do not disappear, and when initial effects are large, long - term effects remain substantial.1, 2 Null findings in cognitive and social domains in a few studies may reasonably be attributed to the limitations inherent to their designs, samples, and measures.