Not exact matches
We aim to identify molecular, circuit, and network
mechanisms of
cognitive dysfunction and to develop novel therapeutic approaches to restore brain functions in AD and
related disorders.
Recent estimates suggest that as many as 1.9 million children younger than 18 years have a sport - or recreation -
related concussion each year in the United States.1 This injury is biomechanically induced, with symptoms resulting from neuronal dysfunction due to functional and neurometabolic alterations rather than gross structural abnormalities.2 Compared with boys involved in similar activities, girls experience higher rates of sport -
related concussion,3 - 7 report more severe symptoms,8 - 11 demonstrate worse
cognitive impairment,8 - 10, 12 and take longer to recover.11 The neural
mechanisms behind these postconcussion sex differences are poorly understood but have been attributed to differences in neuroanatomy and physiology, 13 cerebral blood flow, 14 and the female sex hormones estrogen and progesterone.15 - 17
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mechanisms that underlie age -
related memory loss and
cognitive dysfunction.
The research answered questions
related to impact of the WINGS program on children's relationships, behaviors, and person - centered competencies.The evaluation also collected an exploratory set of building block measures of early
cognitive and emotional skills to better understand the underlying developmental
mechanisms leading to the outcomes.
There is no way, IMO, to seriously consider the
mechanisms of these phenomena without examining more deeply the
related cognitive and psychological elements of human reasoning.
Research also implicates a distributed network within the prefrontal cortex through which attention is deployed to closely monitor performance, incorporating feedback, as individuals then call on more specialized
cognitive control
mechanisms to modify subsequent behaviour.30 - 32 Anxiety
related perturbations in this pattern are evident in both children33 and adults.34 Imaging studies have implicated the anterior cingulate cortex (ACC) in this process, as it appears to be hyperactive in anxious individuals during tasks requiring
cognitive or «top down» control.35
Antenatal depression may not only alter development of stress -
related biological systems in the fetus, but may also increase risk of obstetrical complications.6 Postnatal depression may also be an early life stressor given known associations with lower levels of sensitive, responsive care needed for infants» development of health attachment relationships, emotional regulation skills, interpersonal skills and stress response
mechanisms.7 Early life stressors, such as those that might be associated with maternal depression, can influence brain development, which continues at a rapid pace at least for several years after birth.8 Problems in any of these aspects of development may disrupt the earliest stages of socio - emotional and
cognitive development, predisposing to the later development of depression or other disorders.