Sentences with phrase «cohesin binds»

Our results have revealed that although condensin and cohesin bind to the same gene loci, they direct different association networks (Figure).

Not exact matches

Since the two new DNA strands are caught in the ring, only one cohesin is needed to mark the two, thereby helping the transcription factors to find their original binding region on both DNA strands.

The discovery that virtually all regulatory DNA sequences bind to cohesin may also end up having more direct consequences for patients with cancer or hereditary diseases.

By only analysing DNA sequences that bind to cohesin, roughly one per cent of the genome, it would allow us to analyse an individual's mutations and make it much easier to conduct studies to identify novel harmful mutations,» Martin Enge concludes.

Cohesins are protein complexes that bind two straps of DNA and are implicated in its repair, replication and recombination, as well as in its chromosomal stability, transcription regulation, stem - cell pluripotency, and cell differentiation.

Gamze Gunal (Jessberger, TUD)-- «Stage - specific binding profile of cohesin in resting and switch - activated B lymphocytes» (2013)

«By knowing which of the Cohesin / CTCF bound sites are coming together in physical proximity, we started to go from a linear view of the genome to sets of looping interactions, which led us to these domains, these super enhancer domains, where gene expression enhancement is contained within the loop,» says Jill Dowen, a postdoctoral researcher in Young's lab.

Interestingly, when mouse neural precursor cells were examined for similar Cohesin / CTCF - bound loops, not only did the cells have such loops, but they were in similar locations as in the ESC genome.

Stage - specific binding profiles of cohesin in resting and activated B lymphocytes suggest a role for cohesin in immunoglobulin class switching and maturation.