Sentences with phrase «cohesin complexes»

More specifically, we have been studying the roles of the condensin and cohesin complexes in 3D genome organization in the fission yeast, mouse and human systems.

Our ongoing studies demonstrate that the condensin and cohesin complexes are key molecular machines that organize the functional 3D genome structures.

In previous studies, researchers proved in mice that genes of the meiotic cohesin complex produce various degrees of infertility in mice.

CSIC researcher adds: «We have confirmed that mutation is found in both copies of the gene, one inherited from the father and the other one inherited from the mother, in the four women affected by the disease, causing an absolute absence of STAG3 protein and meiotic cohesin complex in these women.

After twenty years of research, the cohesin complex still manages to surprise us regularly, as new functions in new areas of cell cycle regulation come to light.

I also mentioned a protein complex, which is integral for this chromosomal ballet, the cohesin complex.

Not exact matches

Research coordinated by Osaka University has now shown that the nuclear protein complex cohesin must be expressed at sufficient levels in the early mouse brain to control gene regulation and allow development of healthy neuronal networks and behavioral characteristics.

Cohesin encircles the DNA strand as a ring does around a piece of string, and the protein complexes that replicate DNA can pass through the ring without displacing it.

Cohesins are protein complexes that bind two straps of DNA and are implicated in its repair, replication and recombination, as well as in its chromosomal stability, transcription regulation, stem - cell pluripotency, and cell differentiation.

And while we're still far away from completely understanding this complex complex, we already know enough to say that cohesin really is «one ring to rule them all».

And while this feat should already be enough to warrant devoting a whole blog post to cohesin, you will shortly realize that this complex also performs a myriad of other functions during the cell cycle, which really makes it «one ring to rule them all».

Since actual cohesion defects will cause mitotic failure (which most surely results in cell death), most of cohesin - associated diseases are believed to be caused by misregulation of the complex's non-canonical functions in replication / transcription.

These studies demonstrate that the two important protein complexes, condensin and cohesin, are both essential for the assembly of the functional genome architecture, but their roles in the 3D genome organization (gene contacts and topological domain organization) are significantly different.