Sentences with phrase «cohesin organize»
By combining the fission yeast, mouse, and human systems with the latest genomic, genetic, cell biological, and biochemical approaches, we seek to determine how condensin and cohesin organize the functional 3D genome structures and participate in various biological processes, including transcriptional regulation and chromosomal dynamics, and how they contribute to oncogenic processes.
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Our ongoing studies demonstrate that the condensin and cohesin complexes are key molecular machines that organize the functional 3D genome structures.
Cohesin forms small topological chromatin domains of approximately 100 kb, while condensin organizes 300 kb — 1 Mb domains.