Sentences with phrase «cohesin rings»

That poses an obvious problem during S phase: While DNA replication machineries («replisomes») zip along the chromosomes trying to faithfully duplicate the entire genome in a matter of just a couple of hours, they encounter — on average — multiple cohesin rings that are already wrapped around DNA.

The last stage in the life of a cohesin ring is its removal from centromeres, a tightly regulated process, which involves proteolytic cleavage of cohesin's Scc1 / Rad21 subunit (see Figure 2).

Not exact matches

Cohesin encircles the DNA strand as a ring does around a piece of string, and the protein complexes that replicate DNA can pass through the ring without displacing it.

Since the two new DNA strands are caught in the ring, only one cohesin is needed to mark the two, thereby helping the transcription factors to find their original binding region on both DNA strands.

There is good evidence that initial cohesin loading is already topological (meaning, the ring closes around the single chromatid).

And while we're still far away from completely understanding this complex complex, we already know enough to say that cohesin really is «one ring to rule them all».

And while this feat should already be enough to warrant devoting a whole blog post to cohesin, you will shortly realize that this complex also performs a myriad of other functions during the cell cycle, which really makes it «one ring to rule them all».