Sentences with phrase «cohort of patients»

Therefore, numerous research activities address these issues in order to provide beta cell replacement therapy to a broader cohort of patients with diabetes.

This is a pilot study for a larger cohort of patients using this methodology.

This study demonstrates the importance of a well - characterized cohort of patients and controls along with detailed clinical information about their experience of illness.

A phase II basket study is ongoing to determine whether these early results can be confirmed in a much larger cohort of patients.

She has been involved in the identification of early biomarkers of placental damage in cohorts of patients at high risk of pregnancy complications, with specific focus on the role of autoimmunity and of vascular inflammation.

Using ddPCR, the team detected and quantified five strains of HPV cfDNA in blood samples from a small cohort of patients with recurrent metastatic HPV - positive OPSCC, who were undergoing either conventional treatment or immunotherapy.

Data on those who received alvimopan was prospectively collected and compared to a historical cohort of patients who did not receive the drug.

The results were confirmed in a genome - wide association study and replicated in 1,745 patients in four independent cohorts of patients with IBS and control subjects.

They analyzed the association between body mass index (weight divided by height) and progression - free survival (PFS) and overall survival (OS) in six independent cohorts of patients treated with targeted therapy, immunotherapy or chemotherapy in pivotal trials that led to FDA approval of these drugs.

The blood samples analyzed were collected from a small cohort of patients undergoing treatment for metastatic prostate cancer.

The UC research team looked at 3,679 individuals with Type 2 diabetes from a de-identified cohort of patients at the Cincinnati Veterans Affairs Medical Center and who were followed for a 10 - year period, explains Charuhas Thakar, MD, professor and director of the UC Division of Nephrology, Kidney CARE Program.

Among a smaller cohort of patients for whom serum sRAGE levels were available, there were lower levels seen in those taking short - acting CCBs compared with any other type of antihypertensive medication (P =.032).

«This work was exciting because we replicated the previous finding of neuron hyperexcitability in neurons derived from a new cohort of patients diagnosed by a different psychiatrist, confirming the robustness of this characteristic and its potential use for drug development,» says Renata Santos, co-first author and a Salk research collaborator.

«The findings need to be confirmed using targeted RNA sequencing, or internal validation, and then tested in a new cohort of patients, or external validation.

«The first cohort of patients in this two - cohort dose escalation study of the VC - 01 product candidate is currently being assessed at a single site in the United States.

This study reports on a different cohort of patients from Bologna who received an idiosyncratic and rather eclectic form of CBT which included advice on lifestyle changes and a form of «well being therapy.»

Use our advance computer vision, deep learning and artificial intelligence technologies to analyze your own cohorts of patients to gain genomic insights and discoveries

«Our new study indicates that a differential therapeutic approach can be beneficial for older patients in melanoma and suggests that age should be taken into account to design better treatments for certain cohorts of patients.»

It has been made possible by the medical imaging processing skills of the Institut de Neurosciences de la Timone (CNRS / Aix - Marseille Université) and access to a homogeneous cohort of patients diagnosed at a very young age and all assessed using the same protocol at the Centre de Ressources Autisme PACA.

The trial investigated the drug in two separate cohorts of patients: Cohort A, which included 170 patients with heavily pretreated metastatic triple negative breast cancer (mTNBC) regardless of PD - L1 expression, and Cohort B, which included 52 patients with PD - L1 - positive tumors who received it as first - line therapy.

We got permission to continue following the patients in this study and we also recruited a second cohort of patients to try to run a series of placebo controlled studies.

Dr. Anne, together with first author Harriet Eldredge - Hindy, M.D., showed that this same cohort of patients will likely have a reduced risk of ischemic heart disease after 10 years.

For the study, the researchers studied 769 patients enrolled in the TBI Model Systems database, an ongoing multi-center cohort of patients funded by the National Institute on Disability and Rehabilitation Research.

DGCB provides the clinics with concepts and protocols to be tested, at the same time the reverse translation takes place: detailed analysis of cohorts of patients can help unravel physiological mechanisms.

«Women who have breast cancer continue to present with palpable masses even in this contemporary cohort of patients,» said study co-author Jamie Caughran, MD, of Saint Mary's Lacks Cancer Center in Grand Rapids, Michigan, during the press event.

The median age of the full cohort of patients was 45.0 years, and 53 % were male.

This Finnish nationwide cohort study examines the comparative effectiveness of pharmacologic treatments in the prevention of rehospitalization in a nationwide cohort of patients with bipolar disorder.

Conclusions and Relevance The study results, derived from a large cohort of patients with long follow - up time, suggest that the rate of revision septorhinoplasty is low, but certain patient characteristics are associated with higher revision rates.

«Completing enrollment and dosing of the first cohort of patients receiving 20 million AST - OPC1 cells marks another important milestone for our SCiStar study.

They evaluated four independent cohorts of patients with metastatic GEA.

Outlier - based identification of copy number variations using targeted resequencing in a small cohort of patients with tetralogy of fallot

This led to the collection of bone marrow samples from larger cohorts of patients with the Ottawa Hospital Research Institute, as well as those from Western University and Hamilton Health Sciences, for the next steps of investigation.

The company is partnering up with a group of clinicians at Stanford, as well as telemedicine vendor American Well, to test whether Apple Watch's heart rate sensor can detect abnormal heart rhythms in a cohort of patients, according to two people familiar.

Khachaturian says a proper test of Roses» findings — using Roses» methods in a larger cohort of patients — has not yet been done.

Adams points out that Cohort A is the first phase II study of an immunotherapy for triple negative breast cancer to be reported and represents the largest cohort of patients with mTNBC treated with immunotherapy to date.

The study used the largest cohort of patients and the longest follow - up for TRT to date.

And for researchers studying the organ, new questions are emerging about how the environment, lifestyle or genetics of this small cohort of patients might predispose them to appendicitis even as it becomes less common.

In the cohort of patients who received transplants from mismatched unrelated donors, all 43 patients received four doses of abatacept with a calcineurin inhibitor and methotrexate.

The team then validated these findings in a cohort of patients with type 2 diabetes.

The earlier discovery of mutations in UBQLN2 gene, which causes ALS and ALS / dementia in children and adults, in the Siddique lab led to the screening of the UBQLN family of genes in a large cohort of patients with familial ALS, resulting in the identification of the UBQLN4 mutation.

Conducting a cross-sectional study of a large cohort of patients with different levels of cognitive impairment and different disease stages, the researchers found that the amounts of a TREM2 fragment in the cerebrospinal fluid were highest during early stages characterized by mild cognitive impairment symptoms.

The researchers plan to continue studying this cohort of patients over time to gain a better understanding of how the disease evolves in individual patients.

A cohort of patients treated with the immune checkpoint inhibitor ipilimumab (207 patients) showed similar results.

This led us to review our large cohort of patients and screen them for common medications, focusing on antacids.

Now a team of UCLA researchers has shown for the first time in a large cohort of patients that electroconvulsive therapy (ECT), sometimes referred to as shock treatment, change certain areas of the brain that play a role in how people feel, learn and respond to positive and negative environmental factors.

Additional potential novel biomarkers will also be evaluated and reported in this cohort of patients.

You found it by looking for rare germline variants in a cohort of patients with a specific form of cancer.