Sentences with phrase «cohort of patients with»

This Finnish nationwide cohort study examines the comparative effectiveness of pharmacologic treatments in the prevention of rehospitalization in a nationwide cohort of patients with bipolar disorder.

Prevalence of parietal cell antibodies in a large cohort of patients with autoimmune thyroiditis.

Conti V, Leone MC, Casato M, Nicoli M, Granata G, Carlesimo M. High prevalence of gluten sensitivity in a cohort of patients with undifferentiated connective tissue disease.

Here, we report the largest cohort of patients with HUWE1 variants, consisting of 14 females and 7 males, with 15 different missense variants and one splice site variant.

Tanguy Seiwert, M.D., of The University of Chicago, presented results of a phase 1b trial of Merck's pembrolizumab in a cohort of patients with advanced head and neck cancer.

Outlier - based identification of copy number variations using targeted resequencing in a small cohort of patients with tetralogy of fallot

Using ddPCR, the team detected and quantified five strains of HPV cfDNA in blood samples from a small cohort of patients with recurrent metastatic HPV - positive OPSCC, who were undergoing either conventional treatment or immunotherapy.

The study results, derived from a large cohort of patients with long follow - up time, suggest that the rate of revision septorhinoplasty is low, but certain patient characteristics are associated with higher revision rates.

You found it by looking for rare germline variants in a cohort of patients with a specific form of cancer.

Conclusions and Relevance The study results, derived from a large cohort of patients with long follow - up time, suggest that the rate of revision septorhinoplasty is low, but certain patient characteristics are associated with higher revision rates.

Conducting a cross-sectional study of a large cohort of patients with different levels of cognitive impairment and different disease stages, the researchers found that the amounts of a TREM2 fragment in the cerebrospinal fluid were highest during early stages characterized by mild cognitive impairment symptoms.

«The study represents the largest cohort of patients with OACICH to date and reports 2 clinically valuable associations.

The earlier discovery of mutations in UBQLN2 gene, which causes ALS and ALS / dementia in children and adults, in the Siddique lab led to the screening of the UBQLN family of genes in a large cohort of patients with familial ALS, resulting in the identification of the UBQLN4 mutation.

The team then validated these findings in a cohort of patients with type 2 diabetes.

Adams points out that Cohort A is the first phase II study of an immunotherapy for triple negative breast cancer to be reported and represents the largest cohort of patients with mTNBC treated with immunotherapy to date.

This led to the collection of bone marrow samples from larger cohorts of patients with the Ottawa Hospital Research Institute, as well as those from Western University and Hamilton Health Sciences, for the next steps of investigation.

The results were confirmed in a genome - wide association study and replicated in 1,745 patients in four independent cohorts of patients with IBS and control subjects.

They evaluated four independent cohorts of patients with metastatic GEA.

Not exact matches

The company is partnering up with a group of clinicians at Stanford, as well as telemedicine vendor American Well, to test whether Apple Watch's heart rate sensor can detect abnormal heart rhythms in a cohort of patients, according to two people familiar.

In the first study evaluating patient - reported cosmetic outcomes in a population - based cohort of older women with breast cancer, The University of Texas MD Anderson Cancer Center researchers found that less radiation was associated with improved cosmetic satisfaction long - term.

While further study of larger patient groups with longer follow - up times is needed for this cohort of prostate cancer patients, this study is pivotal in providing evidence for change in practice.»

Overall toxicity levels were similar across groups only for acute side effects (i.e., those that occur closely following treatment), with eight percent of patients in each cohort reporting acute grade 3 + side effects.

The UC research team looked at 3,679 individuals with Type 2 diabetes from a de-identified cohort of patients at the Cincinnati Veterans Affairs Medical Center and who were followed for a 10 - year period, explains Charuhas Thakar, MD, professor and director of the UC Division of Nephrology, Kidney CARE Program.

Another problem is that modeling studies, like this one, are inherently less powerful than other kinds of medical research: randomized clinical trials, the gold standard in medical research, in which patients are randomly assigned different treatments or no treatment; case - control studies, which compare patients who have a condition with those who do not; or cohort studies, which determine the risk of contracting a disease by studying a group of people with similar demographics.

The same rules were applied to a validation cohort of 20 patients (13 with MS and 7 with other lesions) by a blinded observer.

Within the test cohort, all patients with MS had central veins in more than 45 per cent of brain lesions, while the rest had central veins visible in less than 45 per cent of lesions.

Medical historian Flurin Condrau of the University of Zurich in Switzerland, who is not involved in the project, says the notes are a great resource for historians, with a dream cohort of tens of thousands of patients over nearly 4 decades.

Initially a test cohort of 10 patients with MS and 10 patients with non-MS white brain matter lesions were scanned.

After a 15 - month follow up, 16 patients from two cohorts had partial responses, with an overall response rate of 38 and 27 percent in each of the two cohorts.

The trial investigated the drug in two separate cohorts of patients: Cohort A, which included 170 patients with heavily pretreated metastatic triple negative breast cancer (mTNBC) regardless of PD - L1 expression, and Cohort B, which included 52 patients with PD - L1 - positive tumors who received it as first - line therapy.

In a matched cohort of 1,706 patients in each arm, the researchers still found an overall survival benefit with BCT over mastectomy in the HR positive subset but not in the HR negative subset.

In the second cohort of 77 COPD patients, the 23 patients with allergic sensitization (determined by immunoglobulin E testing) were significantly more likely to wheeze, to experience nighttime awakening due to cough, and to have COPD exacerbations requiring antibiotic treatment or an acute visit to the doctor.

Researchers conducted a population - based perspective birth cohort study of 7,046 pregnant women, and categorized subjects into three groups: negative anti-tTG (control), intermediate anti-tTG (just below the clinical cut - off point used to diagnose patients with celiac disease) and positive anti-tTG (highly probable celiac disease patients).

«Accordingly, we examined the effects of allergic disease on respiratory health in two sets of patients with COPD, one a nationally representative sample of 1,381 COPD patients from the National Health and Nutrition Survey III (NHANES III) and the other a cohort of 77 former smokers with COPD from a study of the effects of endotoxin exposure on health status.»

In the cohort of patients who received transplants from mismatched unrelated donors, all 43 patients received four doses of abatacept with a calcineurin inhibitor and methotrexate.

The second cohort of 140 patients with human leukocyte antigen - matched unrelated donor transplants completed enrollment in November 2017, with data expected from this randomized double - blind arm of the study in the next six months.

Dr Matt Hurles, who led the study from the Sanger Institute, said: «This study has the largest cohort of such families in the world, and harnesses the power of the NHS, with 200 clinical geneticists and 4,000 patients.

Researchers were able to access CSF samples from the deprenyl and tocopherol antioxidative therapy of Parkinsonism (DATATOP) study, which is the largest cohort assembled to date with longitudinal collection of biological fluids and clinical data from PD patients.

«The cohort study has found that the sofosbuvir / daclatasvir combination is associated with a high rate of SVR4 in difficult - to - treat patients infected by genotype - 1 hepatitis C.

The researchers identified a cohort of 7,704 RA patients from the Swedish Biologics Register with no previous incidence of ischemic heart disease who started their first TNF inhibitor between 2001 and 2010.

Dr. Anne, together with first author Harriet Eldredge - Hindy, M.D., showed that this same cohort of patients will likely have a reduced risk of ischemic heart disease after 10 years.

A comparator cohort of 23,112 matched, patients with RA who had never taken a biologic were identified from the National Patient Register.

A cohort of patients treated with the immune checkpoint inhibitor ipilimumab (207 patients) showed similar results.

They analyzed the association between body mass index (weight divided by height) and progression - free survival (PFS) and overall survival (OS) in six independent cohorts of patients treated with targeted therapy, immunotherapy or chemotherapy in pivotal trials that led to FDA approval of these drugs.

Obese patients with metastatic melanoma who are treated with targeted or immune therapies live significantly longer than those with a normal body mass index (BMI), investigators report in a study published in Lancet Oncology of 1,918 patients in six independent clinical cohorts.

«Furthermore, analysis of tumor samples from large cohorts of colorectal cancer patients revealed that activation of the loop is associated with metastasis,» Hermeking reports.

Evaluation of 66 patients with JDM, recruited from the UK JDM Cohort and Biomarker Study and actively treated with anti-TNF agents, showed significant improvements in muscle and skin involvement, as well as in overall disease activity.

They analyzed a large cohort of human patient samples from the human kidney biobank managed by Susztak and found that the interconversion might also occur in patients with kidney disease and likely contributes to a condition when the kidneys can not remove enough acid from the body.

«Now that spinal stimulation has been successful in four out of four patients, there is evidence to suggest a large cohort of individuals, previously with little realistic hope of any meaningful recovery from spinal cord injury, may benefit from this intervention.»

The study enrolled 100 patients with de novo coronary lesions 2.25 - 3.50 mm in diameter and length ≤ 27 mm in two 50 - patient cohorts for angiographic, intravascular ultrasound, and clinical assessment at nine or 24 months, with optical coherence tomography (OCT) performed in a subset of 30 patients at multiple time periods.