Sentences with phrase «cohorts of patients treated»

They analyzed the association between body mass index (weight divided by height) and progression - free survival (PFS) and overall survival (OS) in six independent cohorts of patients treated with targeted therapy, immunotherapy or chemotherapy in pivotal trials that led to FDA approval of these drugs.

A cohort of patients treated with the immune checkpoint inhibitor ipilimumab (207 patients) showed similar results.

Not exact matches

In Cohort A, pembrolizumab shrunk tumors by more than 30 percent in eight of 170 patients, or five percent, and stabilized the disease in 35, or 21 percent, of those previously treated for mTNBC.

Adams points out that Cohort A is the first phase II study of an immunotherapy for triple negative breast cancer to be reported and represents the largest cohort of patients with mTNBC treated with immunotherapy toCohort A is the first phase II study of an immunotherapy for triple negative breast cancer to be reported and represents the largest cohort of patients with mTNBC treated with immunotherapy tocohort of patients with mTNBC treated with immunotherapy to date.

«The cohort study has found that the sofosbuvir / daclatasvir combination is associated with a high rate of SVR4 in difficult - to - treat patients infected by genotype - 1 hepatitis C.

We hope that this helps support further treatment options for difficult - to - treat patients,» said Professor Stanislas Pol, Hôpital Cochin, Paris, France, principal investigator of the French ANRS CO-22 Hepather cohort.

Obese patients with metastatic melanoma who are treated with targeted or immune therapies live significantly longer than those with a normal body mass index (BMI), investigators report in a study published in Lancet Oncology of 1,918 patients in six independent clinical cohorts.

Evaluation of 66 patients with JDM, recruited from the UK JDM Cohort and Biomarker Study and actively treated with anti-TNF agents, showed significant improvements in muscle and skin involvement, as well as in overall disease activity.

They used exome sequencing and immunostaining of DNA damage response proteins in order to evaluate HRR, and findings were then validated in a cohort of breast cancer patients with BRCA1 / 2 mutations who were treated with PARP inhibitors.

One hundred and forty patients were treated with CHOP - based chemotherapy in a historical cohort of Shanghai Ruijin Hospital from 1997 to 2011, and referred to as the training cohort.

In this retrospective cohort study — meaning the patients in the study already had thyroid cancer and were known to have been exposed to the TMI accident — lead researcher Dr. David Goldenberg, professor of surgery, and colleagues identified 44 patients who were treated at the Penn State Health Milton S. Hershey Medical Center for the most common type of thyroid cancer, papillary thyroid cancer, between 1974 and 2014.

Genome - wide association study (GWAS) data from a prospective cohort of warfarin - treated patients (n = 711) was also analyzed for genetic variations across the CYP4F gene cluster.

Known and novel independent prognostic markers were identified in our cohort of proteasome inhibitor and IMiD - treated patients with long follow - up, including events with context - specific prognostic value, such as deletions of the PRDM1 gene.

Based on an analysis of bowel symptoms recorded using the Gastrointestinal Symptom Rating Scale, researchers reported that despite the use of a gluten free diet — universally indicated for coeliac disease (CD)-- a proportion of their cohort still presented with «persistent symptoms» and it is within this cohort they were aiming to see whether: «abnormal intestinal microbiota may be associated with persisting gastrointestinal symptoms in treated celiac disease patients... [found] higher relative abundance of Proteobacteria and a lower abundance of Bacteroidetes and Firmicutes.»