They evaluated four independent
cohorts of patients with metastatic GEA.
The results were confirmed in a genome - wide association study and replicated in 1,745 patients in four independent
cohorts of patients with IBS and control subjects.
This led to the collection of bone marrow samples from larger
cohorts of patients with the Ottawa Hospital Research Institute, as well as those from Western University and Hamilton Health Sciences, for the next steps of investigation.
Adams points out that Cohort A is the first phase II study of an immunotherapy for triple negative breast cancer to be reported and represents the largest
cohort of patients with mTNBC treated with immunotherapy to date.
The team then validated these findings in
a cohort of patients with type 2 diabetes.
The earlier discovery of mutations in UBQLN2 gene, which causes ALS and ALS / dementia in children and adults, in the Siddique lab led to the screening of the UBQLN family of genes in a large
cohort of patients with familial ALS, resulting in the identification of the UBQLN4 mutation.
«The study represents the largest
cohort of patients with OACICH to date and reports 2 clinically valuable associations.
Conducting a cross-sectional study of a large
cohort of patients with different levels of cognitive impairment and different disease stages, the researchers found that the amounts of a TREM2 fragment in the cerebrospinal fluid were highest during early stages characterized by mild cognitive impairment symptoms.
Conclusions and Relevance The study results, derived from a large
cohort of patients with long follow - up time, suggest that the rate of revision septorhinoplasty is low, but certain patient characteristics are associated with higher revision rates.
You found it by looking for rare germline variants in
a cohort of patients with a specific form of cancer.
The study results, derived from a large
cohort of patients with long follow - up time, suggest that the rate of revision septorhinoplasty is low, but certain patient characteristics are associated with higher revision rates.
Using ddPCR, the team detected and quantified five strains of HPV cfDNA in blood samples from a small
cohort of patients with recurrent metastatic HPV - positive OPSCC, who were undergoing either conventional treatment or immunotherapy.
Outlier - based identification of copy number variations using targeted resequencing in a small
cohort of patients with tetralogy of fallot
Tanguy Seiwert, M.D., of The University of Chicago, presented results of a phase 1b trial of Merck's pembrolizumab in
a cohort of patients with advanced head and neck cancer.
Here, we report the largest
cohort of patients with HUWE1 variants, consisting of 14 females and 7 males, with 15 different missense variants and one splice site variant.
Conti V, Leone MC, Casato M, Nicoli M, Granata G, Carlesimo M. High prevalence of gluten sensitivity in
a cohort of patients with undifferentiated connective tissue disease.
Prevalence of parietal cell antibodies in a large
cohort of patients with autoimmune thyroiditis.
This Finnish nationwide cohort study examines the comparative effectiveness of pharmacologic treatments in the prevention of rehospitalization in a nationwide
cohort of patients with bipolar disorder.
Not exact matches
The company is partnering up
with a group
of clinicians at Stanford, as well as telemedicine vendor American Well, to test whether Apple Watch's heart rate sensor can detect abnormal heart rhythms in a
cohort of patients, according to two people familiar.
In the first study evaluating
patient - reported cosmetic outcomes in a population - based
cohort of older women
with breast cancer, The University
of Texas MD Anderson Cancer Center researchers found that less radiation was associated
with improved cosmetic satisfaction long - term.
While further study
of larger
patient groups
with longer follow - up times is needed for this
cohort of prostate cancer
patients, this study is pivotal in providing evidence for change in practice.»
Overall toxicity levels were similar across groups only for acute side effects (i.e., those that occur closely following treatment),
with eight percent
of patients in each
cohort reporting acute grade 3 + side effects.
The UC research team looked at 3,679 individuals
with Type 2 diabetes from a de-identified
cohort of patients at the Cincinnati Veterans Affairs Medical Center and who were followed for a 10 - year period, explains Charuhas Thakar, MD, professor and director
of the UC Division
of Nephrology, Kidney CARE Program.
Another problem is that modeling studies, like this one, are inherently less powerful than other kinds
of medical research: randomized clinical trials, the gold standard in medical research, in which
patients are randomly assigned different treatments or no treatment; case - control studies, which compare
patients who have a condition
with those who do not; or
cohort studies, which determine the risk
of contracting a disease by studying a group
of people
with similar demographics.
The same rules were applied to a validation
cohort of 20
patients (13
with MS and 7
with other lesions) by a blinded observer.
Within the test
cohort, all
patients with MS had central veins in more than 45 per cent
of brain lesions, while the rest had central veins visible in less than 45 per cent
of lesions.
Medical historian Flurin Condrau
of the University
of Zurich in Switzerland, who is not involved in the project, says the notes are a great resource for historians,
with a dream
cohort of tens
of thousands
of patients over nearly 4 decades.
Initially a test
cohort of 10
patients with MS and 10
patients with non-MS white brain matter lesions were scanned.
After a 15 - month follow up, 16
patients from two
cohorts had partial responses,
with an overall response rate
of 38 and 27 percent in each
of the two
cohorts.
The trial investigated the drug in two separate
cohorts of patients:
Cohort A, which included 170
patients with heavily pretreated metastatic triple negative breast cancer (mTNBC) regardless
of PD - L1 expression, and
Cohort B, which included 52
patients with PD - L1 - positive tumors who received it as first - line therapy.
In a matched
cohort of 1,706
patients in each arm, the researchers still found an overall survival benefit
with BCT over mastectomy in the HR positive subset but not in the HR negative subset.
In the second
cohort of 77 COPD
patients, the 23
patients with allergic sensitization (determined by immunoglobulin E testing) were significantly more likely to wheeze, to experience nighttime awakening due to cough, and to have COPD exacerbations requiring antibiotic treatment or an acute visit to the doctor.
Researchers conducted a population - based perspective birth
cohort study
of 7,046 pregnant women, and categorized subjects into three groups: negative anti-tTG (control), intermediate anti-tTG (just below the clinical cut - off point used to diagnose
patients with celiac disease) and positive anti-tTG (highly probable celiac disease
patients).
«Accordingly, we examined the effects
of allergic disease on respiratory health in two sets
of patients with COPD, one a nationally representative sample
of 1,381 COPD
patients from the National Health and Nutrition Survey III (NHANES III) and the other a
cohort of 77 former smokers
with COPD from a study
of the effects
of endotoxin exposure on health status.»
In the
cohort of patients who received transplants from mismatched unrelated donors, all 43
patients received four doses
of abatacept
with a calcineurin inhibitor and methotrexate.
The second
cohort of 140
patients with human leukocyte antigen - matched unrelated donor transplants completed enrollment in November 2017,
with data expected from this randomized double - blind arm
of the study in the next six months.
Dr Matt Hurles, who led the study from the Sanger Institute, said: «This study has the largest
cohort of such families in the world, and harnesses the power
of the NHS,
with 200 clinical geneticists and 4,000
patients.
Researchers were able to access CSF samples from the deprenyl and tocopherol antioxidative therapy
of Parkinsonism (DATATOP) study, which is the largest
cohort assembled to date
with longitudinal collection
of biological fluids and clinical data from PD
patients.
«The
cohort study has found that the sofosbuvir / daclatasvir combination is associated
with a high rate
of SVR4 in difficult - to - treat
patients infected by genotype - 1 hepatitis C.
The researchers identified a
cohort of 7,704 RA
patients from the Swedish Biologics Register
with no previous incidence
of ischemic heart disease who started their first TNF inhibitor between 2001 and 2010.
Dr. Anne, together
with first author Harriet Eldredge - Hindy, M.D., showed that this same
cohort of patients will likely have a reduced risk
of ischemic heart disease after 10 years.
A comparator
cohort of 23,112 matched,
patients with RA who had never taken a biologic were identified from the National
Patient Register.
A
cohort of patients treated
with the immune checkpoint inhibitor ipilimumab (207
patients) showed similar results.
They analyzed the association between body mass index (weight divided by height) and progression - free survival (PFS) and overall survival (OS) in six independent
cohorts of patients treated
with targeted therapy, immunotherapy or chemotherapy in pivotal trials that led to FDA approval
of these drugs.
Obese
patients with metastatic melanoma who are treated
with targeted or immune therapies live significantly longer than those
with a normal body mass index (BMI), investigators report in a study published in Lancet Oncology
of 1,918
patients in six independent clinical
cohorts.
«Furthermore, analysis
of tumor samples from large
cohorts of colorectal cancer
patients revealed that activation
of the loop is associated
with metastasis,» Hermeking reports.
Evaluation
of 66
patients with JDM, recruited from the UK JDM
Cohort and Biomarker Study and actively treated
with anti-TNF agents, showed significant improvements in muscle and skin involvement, as well as in overall disease activity.
They analyzed a large
cohort of human
patient samples from the human kidney biobank managed by Susztak and found that the interconversion might also occur in
patients with kidney disease and likely contributes to a condition when the kidneys can not remove enough acid from the body.
«Now that spinal stimulation has been successful in four out
of four
patients, there is evidence to suggest a large
cohort of individuals, previously
with little realistic hope
of any meaningful recovery from spinal cord injury, may benefit from this intervention.»
The study enrolled 100
patients with de novo coronary lesions 2.25 - 3.50 mm in diameter and length ≤ 27 mm in two 50 -
patient cohorts for angiographic, intravascular ultrasound, and clinical assessment at nine or 24 months,
with optical coherence tomography (OCT) performed in a subset
of 30
patients at multiple time periods.