Sentences with phrase «collection of cells lining»

Until 2009, Saitou's starting point had been cells taken from a live mouse epiblast — a cup - like collection of cells lining one end of the embryo that forms at the end of the first week of development, just before the PGCs emerge.

Since our collection of cell lines is completely genetically annotated — which means that mutations and expression changes in each line's genes have been documented — we should be able to identify in advance patients who will benefit from specific combinations.

The European Collection of Cell Cultures (ECACC) provides the research community with a rich collection of cell lines.

Not exact matches

«We wanted to see whether very - large - scale screening across a diverse collection of cancer cell lines and a large number of drugs could yield new combinations for patients with cancer,» says Adam Friedman, MD, PhD, of the CBRC and the MGH Cancer Center, who led the study.

Three levels of parental ES cell lines are available for E14Tg2a.4 (BayGenomics and Sanger Institute Gene Trap Resource (SIGTR)-RRB- and AK7 (Soriano) cell line collections; only Level 2 of parental ES cell line is available for the Nagy collection - see item 2 below:

Normalized (QNORM): The shape of the expression profile for each cell line is normalized such that all of the data for the collection is on the same scale (4 as minimally / not expressed, 15 as a maximum readout).

In case of the Sanger Institute, lines of interest can be nominated from the Sanger ES cell collection from which then a KO mouse line will be produced and phenotyped.

We took advantage of this collection of JAK1 mutation - positive autonomous cell lines to study the sensitivity of different JAK1 mutations to JAK inhibitors.

Beyond the expansion of the collection of barcoded cell lines for testing larger panels of compounds, next steps will include determining whether PRISM can be used to study the complex interactions between different cell types found within tumors, or to study tumor evolution during cancer development or after cancer treatment.

These stem cell lines represent the largest collection of lines for a variety of neuropathy disorders of known genetic causation.

An inverse correlation has been found between DAXX and DAPK1 / 3 mRNA expression in a diverse collection of human tumor cell lines and tumor specimens [Submitted], suggesting that DAXX's role as a transcriptional repressor of DAPK1 / 3 [2] is broadly relevant to tumor biology and is not restricted to PCa.

The Coriell Institute provides information about stem cells and holds a considerable collection of tissue samples, cell lines and pluripotent stem cells.

The MMRRC currently holds 24 mouse models and several ES cell lines from this collection and the MMRRC at UC Davis will generate an additional group of mouse models for this collection from the supplied ES cells.

The Sanger Institute Gene Trap Resource (SIGTR) mouse ES cell line collection was developed to provide a powerful and cost effective approach using gene trapping to create large numbers of insertional mutations that are immediately accessible to molecular characterization.