Here the authors, using an ex-vivo model, show that cancer - associated fibroblasts facilitate
colon cancer cells invasion in a matrix metalloproteinase - independent manner, likely by pulling and stretching the basement membrane to form gaps.
Not exact matches
In co-culture experiments on coated transfilters, both NAFs and CAFs induced migration and
invasion of HT29, which are intrinsically noninvasive
colon cancer cells.
They help block the ability of
cancer cells to produce the tumor
invasion enzyme in the first place, in both human
colon cancer cells, and human breast
cancer.