Based upon these data, we hypothesize that strain - selective activation of NF - kB and / or MAPK by H. pylori cag + strains regulates MMP - 7 expression, which may contribute to the augmentation in carcinogenic risk associated with these strains by attenuating apoptosis within chronically
colonized mucosa.
Not exact matches
Staphylococcus aureus is part of the natural skin flora, preferentially
colonizing external
mucosa in 30 to 50 % of the population, healthy carriers who develop no symptoms.
Our experiments have recently shown that MMP - 7 is detected exclusively in human
mucosa colonized by cag + strains, and these same H. pylori strains selectively induce MMP - 7 in vitro through cag - mediated activation of NF - kB and MAPK.