Not exact matches
But scientists say that it has potential for even better resolution and for examining protein - protein interactions, particularly if
fluorescent labels of different
colors can be applied to proteins.
Such vectors have become critical tools for delivering genes to treat disease or to
label neurons and their connective fibers with
fluorescent colors to map out their locations.
The
fluorescent green, yellow and blue signals enabled the researchers to
label different synapses activated by the sensory experience in different
colors in the same animal.
Because zebrafish are transparent until their stripes emerge in adulthood, Oehlers could
label the bacteria, immune cells, and vasculature with differently
colored fluorescent tags and then follow a TB infection over time.
The same principle lies behind the powerful and visually spectacular Brainbow cell -
labeling technique, in which each
labeled cell expresses a unique ratio of three or four distinct
colors of
fluorescent protein.
One common complaint about using four -
color Confetti to
label single cells (in an animal) is that the cells express green
fluorescent protein less often, or sometimes not at all, compared with cells that express each of the other three
colors.
Human induced pluripotent stem cell neurons imaged in phase contrast (gray pixels, left)-- currently processed manually with
fluorescent labels (
color pixels) to make them visible.