Lineage - restricted progenitors are identifiable by expression of distinct
combinations of cell surface markers.
In breast cancer, CSCs or tumor - initiating cells were first identified by using
a combination of cell surface markers, CD24 − / CD44 + / ESA (EpCAM) + (2).
Not exact matches
By means
of a non-obese diabetic / severe combined immunodeficiency disease (NOD / SCID) xenotransplant assay in
combination with specific
cell surface markers (CD44 + CD24 - / low), CSCs were enriched from metastatic and primary breast tumors and were shown to have the ability to reestablish tumor heterogeneity after transplantation [1].