Sentences with phrase «combined effect produces»

All these hormones send signals to the brain based on a variety of factors like blood glucose levels, or when someone is eating something and cumulatively, their combined effect produces a sensation called hunger.

Not exact matches

This funnelling effect, combined with the sheer volume of vehicles moving around Greater Vancouver, produces lineups of three kilometres or more every day.

The effects of the empty nest, the menopause, the death of parents, and the unavoidable evidence of one's own aging combine to produce the crisis of the middle years.

The resulting outburst of methane produced effects similar to those predicted by current models of global climate change: a sudden, extreme rise in temperatures, combined with acidification of the oceans.

In another twist, combining the antigen (the vaccine) and CpG causes the body to change its immune response, producing antibodies that dampen the damaging health effects dust - mite allergens generally cause.

In addition, combining the anti-RANKL antibody with ipilimumab produced a synergistic effect and helped prolong survival.

«Combined checkpoint inhibitor treatments, such as ipilimumab - nivolumab, have produced higher response rates, but they can have serious side effects.

One effect of this inequality is that the top 10 percent produce almost as much total carbon emissions as the bottom 90 percent combined.»

Birnbaum, director of both the National Institute for Environmental Health Sciences (NIEHS) and the National Toxicology Program in Washington, D.C., noted that some chemicals, such as those that mimic human hormones, may combine with other hormonelike chemicals at low doses to produce big effects.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

«Using our preclinical model, we will determine what existing chemotherapies can be combined with this novel drug type to produce the best therapeutic effects,» he said.

Brain activity reduction and the fact that no drop in behavioural performance was seen during the task indicates that the brain is more efficient under the 2 substances» combined effect, as fewer resources are needed for producing the same performance level compared to those individuals who had the placebo or who had only glucose or caffeine.

The combined effect of anabolic hormones (testosterone, insulin and growth hormone) produced by your body is what causes muscles to grow.

Experiments in which researchers combined endurance and strength training have not produced statistically significant effects either.

That when you combine caffeine and L theanine, you get better effect and then finally, when you drink L theanine for alertness, it has a similar alertness producing effect as coffee but doesn't keep you awake at night meaning that if you have say, you have a cup of green tea while you're studying at night, you're still gonna be able to sleep whereas coffee can really interfere with your sleep because a lot of people misconstrue or think that you know, the alertness producing compounds in tea or just a different form of caffeine but they're not.

Altering the gut genome from obese to lean has «long lasting effects» when combined with a «healthy diet high in fiber and low in saturated fats,» confirming multiple studies that show «that the food we eat has a direct relationship to the types of bacteria produced in the human digestive system;»

Combining this with Cordyceps helps you to produce and maintain steady energy levels to double coffee's effects while using only half of the caffeine normally found in coffee!

The combination of two or more legal anabolic roids produces a combined effect that is greater than the sum of the separate effects of the steroids.

This effect combined with the slow digesting casein protein produces the optimum muscle building opportunity.

Whilst HBO2T alone has not been shown to offer great improvements in cancer development, combining it with the ketogenic diet appears to produce significant anti-cancer effects in animal models (23).

«A Ketogenic Diet and HBOT produce significant anti-cancer effects when combined in a natural model of systemic metastatic cancer.

Produced for the BBC project «Sound On Film» as a work that had music play a major part in its creation, the piece is a complex montage of bizarre multi-source imagery that Roeg combines with various optical effects and an overarching tone that leans toward the cosmic.

That, Klein aides argue, will show that major reforms in lower grades, like the citywide curriculum and the 3rd - and 5th - grade retention policies, will have combined with reforms to middle schools and high schools to produce their desired effects.

In fact, engineers worked to combine the sounds produced by the air intake system at the front and the exhaust system at the rear to create what they describe as a «concert hall» effect inside the cabin, both as the car gains speed and slows down.

Those levels of torque are produced by the combined effect of the V12 engine and the electric motor which provides instantaneous response at all times.

Combining several methods to relieve pain in dogs will produce maximum effect.

It combines the energy of red and the happiness of yellow, and supposedly increases oxygen supply to the brain — producing an invigorating effect.

He utilizes his exhaustive study of glass manufacturing processes to produce — in his own studio — luminous color effects in blown and molded glass, combined with typically collaborative efforts with experts in wood, metal, etching and photography.

From 1959 to 1961 he lived in New York on a Harkness Fellowship, producing paintings that combined the formal qualities of the work of American abstract painters, with references to American commercial culture, with its lush seductive colours, exploitation of magnification and soft - focus effects and, generally, its stimulation of desire and fantasy.

Ms. Farmanfarmaian's dazzling, mirrored sculptures and jewelry combine architecture, celestial geometry and Sufism with traditional Islamic craft techniques to produce a kaleidoscopic effect.

With the cosmic ray effect we have ~ 0.3 C of solar warming combined with ~ 0.2 of CO2 warming, which is then offset by human - produced aerosols to yield ~ 0.3 of waring.

They should have realised that top down high solar activity combined with bottom up positive oceanic influences would in combination be enough to produce the late 20th century warming without having to invoke a significant effect from more CO2.

Team Purple could check for UHI, albedo change, pollution etc theories to see if those, combined with the greenhouse effect, can produce predictions which actually match reality, something Red's efforts conspicuously fail to do.

Precession refers to the fact that both Earth's rotational axis and orbital path precess (rotate) over time — the combined effects of these two components and the eccentricity produce an approximately 21,000 - year cycle.

Combine the estimates from steps 4 and 5 to produce an assessment of the net economic effect of different scenarios and thereby identify the optimum path of emissions.

There are three primary feedback effects — clouds, sea ice and water vapor; these, combined with other feedback effects, produce the greatest uncertainties in predicting the planet's future climate.

It is shown that deep stratification may readily be produced by the combined effects of surface thermodynamic forcing and geometry.

Combining alcohol with another drug and they are likely to produce a synergistic effect which no one can predict.

The USB Type - C port is on the bottom edge of the device, alongside the the 3.5 mm audio jack and the loudspeaker which - similar to the HTC 10 - combines with a speaker in the earpiece to produce a stereo - like effect.

Boldly advertised as similar to the high - end photographic equipment on the back of the iPhone 7 Plus, the Mi A1's main snapper combines telephoto and wide angle lenses to produce a «DSLR effect», Portrait mode, 2x optical zoom and up to 10x digital zoom.

Details from both these sensors are combined to produce sharp images with depth / bokeh effect.

The work of sight effects specialist has to combine both artistic qualities and the ability to understand artistic requirements of a performance or of the producing personnel, with technical abilities of using lighting and wiring equipment and obtain desired effects by assigning special duties to the electrical crew.

Current research has examined how to produce even more long - lasting effects by combining CBT with alternative medicine.