Sentences with phrase «combined with gene»

It is expected that the knowledge of the functions of these transcription factors, when combined with gene editing techniques, will allow for the efficient regeneration of blood vessels.

Now stem cells are being combined with gene and immune therapies, compounding the pace of progress.

Such a treatment might be combined with a gene therapy approach, also being pursued by her team and other groups, delivered directly to the brain to curtail mHTT expression.

Tissue engineering combined with gene therapy technology has the potential to manage the repair of defective articular cartilage.

Not exact matches

This dataset contains millions of genomic sequences from a diverse set of rice varieties that, when combined with phenotyping observations, gene expression, and other information, provides an important step in establishing gene - trait associations, building predictive models, and applying these models to breeding.

«Using a new approach of combining molecular identification of the SPIKE gene and conventional breeding, we have developed rice, with the SPIKE gene, that has higher yield when compared with an equivalent rice without the gene,» Dr. Kobayashi said.

What do you get when you combine KISS front man Gene Simmons with Master Chef Wolfgang Puck and AEG?

The information collected is then combined with information about the patient's genes, proteins and metabolism to help determine what drug and dose might be best for that person.

They combined spherical nucleic acids (SNAs, which are nanoscale globular forms of RNA) with a common commercial moisturizer to create a way to topically knock down a gene known to interfere with wound healing.

By combining understanding of resistance genes with knowledge of the pathogen, they hope to develop Desiree and Maris Piper varieties that can completely thwart attacks from late blight.

By combining each mouse's genome, phenome, proteome and metabolome, the scientists were able to identify a particular gene, located on their chromosome 2, and whose presence plays an important role in the development of type 2 diabetes «The mice with a high - fat diet are more or less likely to develop diabetes depending on whether this gene is active or not,» said Evan Williams, LISP PhD student and the article's co-first author.

Recent advances combining the gene - editing tool CRISPR — Cas9 (for, clustered, regularly interspaced, short palindromic repeats with a guiding enzyme called Cas9) are now making it easier for scientists to modify a genome such that nearly all offspring inherit the desired trait.

The huge population of viruses, combined with their rapid rates of replication and mutation, makes them the world's leading source of genetic innovation: they constantly «invent» new genes.

«The bolting seed - producing gene in wild beets threatens to become combined with the transgene for herbicide tolerance, which would lead to super-weeds.»

Now a more complex and daunting view is emerging that shows viruses» constant variability — and sometimes deadly innovation — happens as a result of these two factors, combined with influenza's tendency to swap genes among viruses and also to move between geographically separate populations through traveling or migrating hosts.

Aside from the payoff to launders, molecular biologists say the method behind this mushroom madness, described in the current issue of Nature Biotechnology, is the first to combine two gene mutation techniques with shuffling and sorting procedures to improve an enzyme's function.

PARP inhibitors are used primarily to treat tumors linked to defects in BRCA genes, but may show promise in other cancers when combined with other drugs.

He and his colleagues gathered genetic data from 156 frog species and combined this with earlier information about two genes from 145 different frogs, for a total of 301 distinct frog species from all 55 families of frogs.

The fireworks really went off when I realized that I could combine gene therapy with the neural code to make a retinal prosthetic.

Then they examined its contents with cutting - edge mass spectrometry combined with searches of human gene databases.

Even after the cells were taken out of microgravity for up to 30 generations before being combined with the control strain, they maintained 72 per cent of their adaptive advantage, pointing to permanent mutations in the genes rather than merely a temporary adjustment.

Muscle biologists Qi Long Lu and Terence Partridge at the Medical Research Council Clinical Sciences Centre in London, U.K., and their colleagues decided to combined the antisense strategy with a chemical often used in gene therapy because it is known to improve delivery of DNA into cells.

The theory holds that histone proteins, which combine with DNA to form chromosomes, are more intimately involved in gene expression than their general role of facilitating or hindering gene activation suggests.

The researchers from Queen Mary University of London sequenced the HAS2 gene in thirteen similar or related mammals, combining the data with DNA sequences extracted from 57 published genomes representing all the major mammal groups.

Gene mutations involved in enamel mineralization through the CRAC channels were first seen in people with a type of severe combined immunodeficiency, a disorder in which — among other symptoms — tooth enamel may fall off the teeth within five or six years after birth, and the dentine becomes exposed.

A team of scientists, led by Jill L. Maron, MD, MPH, Associate Professor of Pediatrics at Tufts Medical Center, reports that by combining gene amplification techniques with advanced computational analysis tools they were able to identify and validate salivary biomarkers to predict oral feeding readiness in preterm infants.

One current method commonly used today is called chromatin immunoprecipitation, combined with next - generation gene sequencing (ChIP - seq).

Combining this mouse model with the reliable RNA sequences allowed an efficient inactivation of genes in primary cells.

In addition to revealing that biodegradable polymeric nanoparticles represent a promising mode of gene delivery for glioma, the findings show that nonviral DNA delivery of HSVtk combined with administration of ganciclovir has potent antitumor effects.

This could be combined with fluorescence in situ hybridisation (FISH) analysis to detect gene amplification.

The ideal way to identify a gene network in humans would require an impossible experiment: Take two families, each with dozens of identical twins, and have the families interbreed, combining the same sets of genes together over and over again.

Dr. Oesterreich and her colleagues propose that future studies look at offering a combined therapy that, along with aromatase inhibitors, also introduces drugs that modify the epigenome to prevent or delay the cancer from repressing cancer - killing genes.

They combined the protein with synthetic molecules, known as PNAs, that mimic DNA and bind to the target gene to form a triple helix.

The new study — published October 18, 2016 in the journal Molecular Psychiatry — combined genetic analysis of more than 9,000 human psychiatric patients with brain imaging, electrophysiology, and pharmacological experiments in mutant mice to suggest that mutations in the gene DIXDC1 may act as a general risk factor for psychiatric disease by interfering with the way the brain regulates connections between neurons.

«The statistics show that carrying this gene, combined with being infected with hepatitis A, conveys an enormous protection against asthma, allergies, and related diseases,» Umetsu says.

She said: «Identifying a fault in Complex I, one of the building blocks of mitochondria which is responsible for causing disease combined with our custom gene capture and the latest sequencing technology means we can screen many more genes to diagnose this debilitating disease.

When combined with lipids to deliver genes to cells, the transposon chalked up a 20-fold increase of efficiency at inserting genes into chromosomes.

The researchers identified the LSC17 score by sampling the leukemia stem cell properties of blood or bone marrow samples from 78 AML patients from the cancer centre combined with molecular profiling technology that measures gene expression.

In the lab, the scientific team used an approach that combined functional RNAi analysis with gene expression analysis in breast cancer - derived cell lines and in human breast cancers replicated in mice.

A trial of a gene treatment for children with severe combined immunodeficiency, who have no functioning immune system, was called off after some of the patients developed leukaemia.

Phevor works by using algorithms that combine the probabilities of gene mutations being involved in a disease with databases of phenotypes, or the physical manifestation of a disease, and information on gene functions.

The approach combined experimental synthetic biology led by Mark Isalan, now Reader in Gene Network Engineering at the Department of Life Sciences of Imperial College London with computational modelling led by James Sharpe, ICREA Research Professor and head of the Multicellular Systems Biology lab at the CRG.

The never - before - described virus did not involve the novel H1N1 but instead picked up the surface genes from the seasonal human H1N1 virus that has long infected humans and combined them with what's known as the triple - reassortant swine influenza.

New research out of the University of Michigan supports combining two approaches to fight back against gliomas: attacking the tumor with gene therapy while enhancing the immune system's ability to fight it, too.

A mutation in either gene causes it to combine with a partner gene to express an abnormal fusion protein that acts along a cellular growth pathway to result in cancer.

The researchers removed immune cells from the recipient's blood and then disabled a gene in them using CRISPR — Cas9, which combines a DNA - cutting enzyme with a molecular guide that can be programmed to tell the enzyme precisely where to cut.

Researchers investigating pediatric low - grade gliomas (PLGG), the most common type of brain tumor in children, have discovered key biological differences in how mutated genes combine with other genes to drive this childhood cancer.

When the transcript of the M1 RNA gene is combined with the protein moiety not only is a tRNA precursor cleaved but also the precursor to 4.5 S RNA from Escherichia coli.

Combined with the right computational approaches, scNMT - seq has the potential to reveal undiscovered mechanisms of gene regulation, both in development and disease.»

Part of the reason for the difference in drug response, say the authors, is that the fusion partner — the non-kinase gene that BRAF or CRAF combines with — alters the tumor's response.