Sentences with phrase «combining immune checkpoint»
Led by Leena Gandhi, MD, PhD, associate professor of medicine and director of thoracic medical oncology, researchers from the KEYNOTE - 021 study demonstrated for the first time that combining an immune checkpoint inhibitor — in this case, pembrolizumab — with a platinum - doublet chemotherapy regimen might be more effective than chemotherapy alone as first - line treatment for advanced, non-squamous NSCLC.
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One recent tally found more than 1100 studies combining a popular new class called checkpoint inhibitor drugs, which unleash suppressed immune cells, with other treatments.
Once again, researchers at Penn's Abramson Cancer Center have extended the reach of the immune system in the fight against metastatic melanoma, this time by combining the checkpoint inhibitor tremelimumab with an anti-CD40 monoclonal antibody drug.
One phase I trial of an immune checkpoint blockade drug combined with two established targeted therapies yielded 40 - 50 percent response rates among patients with metastatic kidney cancer.
«Cancer treatment for transplant patients discovered: Letter notes combination of steroids and immunosuppressants, combined with immune checkpoint inhibitors helps prevent organ rejection in kidney transplant patients undergoing cancer treatment.»
Dr. Allison: The way the field of immunotherapy is going now is toward combinatorial therapies, where we combine these different immune checkpoints blockers, and also combine these with drugs that actually kill tumor cells.
However, the efficacy of oncolytic viruses still was modest, but can be improved when combined with immune checkpoint inhibitors.
The company is trying to combine and commercialize two very hot technologies — adoptive T - cell therapy and silencing of immune checkpoints by RNAi.
The study highlights an opportunity to combine this form of therapy with cancer immunotherapy drugs such as checkpoint inhibitors, which unleash the immune system's full cancer - fighting power, the researchers say.