We present Temporal FUnctional Metagenomics sequencing (TFUMseq), a platform to functionally mine bacterial genomes for genes that contribute to fitness of
commensal bacteria in vivo.
The functional interactions
of commensal bacteria with intestinal secretory IgA.
Lofgren JL, Whary MT, Ge Z, Muthupalani S, Taylor NS, Mobley M. Lack of
commensal flora in Helicobacter pylori - infected INS - GAS mice reduces gastritis and delays intraepithelial neoplasia.
Though some bloggers are concerned with the safety of Bacillus licheniformis, the latest research suggests that this strain is a healthy, gut
commensal organism designed to protect its human host.
The human gut is loaded
with commensal bacteria — «good» microbes that, among other functions, help the body digest food.
Great underwater scenery, and a great place for macro photography — Living around the soft corals you can find critters including pygmy seahorses, decorator crabs, and many small
commensal species living with crinoids.
Known
as commensal bacteria, resident bugs perform important functions such as breaking down carbohydrates and sugars that people and mice can't.
They can shift the microbiome to restore
normal commensal gut flora, suppress pathogenic overgrowths like Clostridia, and squelch opportunistic pathogens through the use of quorum sensing.
The intestinal microbiota, which is composed of diverse populations of
commensal bacterial species, provides resistance against colonization and invasion by pathogens.
In addition to the expanded use of ARVs in new modalities such as pre-exposure prophylaxis and microbicides [1], this
includes commensal microbicides [2], gene therapies [3], [4] and vaccines [5], [6], [7].
«We identified breast milk as a primary source of IgG antibodies that are directed
against commensal bacteria early in life and demonstrated that this maternally acquired, anti-commensal IgG helps dampen T - helper - cell - driven immune responses against newly encountered microbes.»
When you are not looking into the blue, Koh Bon has excellent critter life including numerous
commensal shrimp species, crabs, nudibranch, bottom dwellers and octopus.
These findings provide unique direct information
on commensal relations, selection processes, and mechanisms of cat domestication in the human niche.
The role of environmental factors such as
commensal intestinal microbiota, and microbial infections and their immunological consequences in genetically susceptible individuals are not yet properly understood.
This contrasts with virtually no human handling at all in sympatric
commensal house mouse populations.
In addition, there are other molecules in breast milk, made by the mother's immune system, that promote tolerance
for commensal microbes while keeping them in the gut and away from the rest of the body.
Ultimately, TFUMseq ‐ based studies could enable the rational design of probiotic or
commensal strains for various clinical applications, such as resisting pathogen colonization, compensating for a high ‐ fat / high ‐ sucrose Western diet, or tempering host autoimmunity.
These results suggest that inhibition of SpdC could be used as an approach to combat S. aureus infections and understand the mechanisms involved in its transition
from commensal to pathogen.
The bacterium, Enterococcus faecalis, is one of
many commensal microbes that live in the human gut (Credit: USDA)
Mshvildadze M, Neu J, Mai V. Intestinal microbiota development in the premature neonate: establishment of a lasting
commensal relationship?.
Writing in the peer reviewed journal Science published online March 13, 2014, the research team writes that this advances our understanding of
how commensal microbes can regulate intestinal immunity and should pave the wave for identifying new drug targets.
«The competition
between commensal house mice and other wild mice continued to fluctuate as humans became more mobile in arid periods and more sedentary at other times — indicating the sensitivity of local environments to degrees of human mobility and the complexity of human environmental relationships going back in the Pleistocene,» said Weissbrod, currently a research fellow at the Zinman Institute of Archaeology at the University of Haifa.
Ample substrate to
nourish commensal flora, in the form of microbiota - accessible carbohydrates (MACs) or prebiotics, is required to restore a healthy ecosystem.
Not only
do commensal bacteria prevent overgrowth of pathogenic bacteria, they also acidify the gut, ferment lactose, breakdown lipids and proteins, and produce vitamins K and biotin.
Here, we reveal a flexible continuum between innate and adaptive immune function in
containing commensal microbes.
Using a «gnotobiotic mouse model» — where mice were «colonized with a synthetic human gut microbiota composed of fully
sequenced commensal bacteria» — Desai et al reported on the effects of different diets with different fibre content.
In these circumstances, the same strains of Candida that grow as
harmless commensals can become pathogenic, invading the mucosa and causing significant damage.
TFUMseq highlights the utility of functional metagenomics for
engineering commensal bacteria with improved properties, including expanded colonization capabilities in vivo.
By contrast, we demonstrate that the prominent gut
commensal Bacteroides fragilis activates the TLR pathway to establish host - microbial symbiosis.
Signaling through innate immune receptors
promotes commensal bacteria colonization of the gut.
Thus, frequent interaction with humans and reduced predation are likely the most important factors that distinguish the study population from
sympatric commensal house mouse populations [16].
This means about 75 - 80 % of your microbiome should be comprised of beneficial bacteria with around 15 - 20 % of being of the
more commensal type.
The Comprehensive Stool Analysis with Parasitology x3 (days) is an invaluable non-invasive diagnostic assessment that permits an objective way to evaluate the status of beneficial and
imbalanced commensal bacteria including Clostridium species, pathogenic bacteria, yeast / fungus and parasites.
Ureaplasmas and M. hominis were often detected in both infertile men and healthy controls, suggesting that they should be
considered commensals.
Distinct
commensals induce interleukin - 1β via NLRP3 inflammasome in inflammatory monocytes to promote intestinal inflammation in response to injury.
We propose that the immune system can discriminate between pathogens and the microbiota through recognition of symbiotic bacterial molecules in a process that engenders
commensal colonization.