We examined the influence of
a common allelic variation in the dopamine receptor D4 (DRD4) gene and caregiver quality on temperament in early childhood.
In humans, disease susceptibility was mapped to a non-coding 6.1 kb 3» region of CTLA4,
the common allelic variation of which was correlated with lower messenger RNA levels of the soluble alternative splice form of CTLA4.
Not exact matches
Allelic complexity in genes will be large, and such complexity will make the analysis of genotype - phenotype relationships difficult, particularly in the situation of
common, complex diseases.
To identify
common functional variants, the authors used an
allelic transmission disequilibrium test (TDT), which determines if an allele is transmitted more (or less) than we'd expect by chance.
This project will inform genomic studies in SSA by providing a reference for
allelic, haplotype and LD structure for
common variants in populations not currently covered by HapMap and the 1000 Genomes projects.