Sentences with phrase «common fragile sites»

Dr. Smith, a professor in the Department of Laboratory Medicine and Pathology, wears many hats at the Mayo Clinic, including running a lab where he works on the characterization of the common fragile sites in the genome and on the role that human papillomaviruses play in the development of a variety of different cancers.

Mapping of XMRV integration sites has revealed a strong preference for structurally open transcription regulatory regions of chromosomes that are associated with cancer breakpoints, common fragile sites, microRNA and cancer - related genes [5].

However, some regions of the genome, notably common fragile sites (CFSs), raise specific problems.

The study results indicate that patients who have abnormal levels of breaks at common fragile sites (CFSs), sites within the chromosomes that are sensitive to DNA damage, are more likely to have their cancer to return — treatment failure.