Sentences with phrase «common gene variants»

«Since our study only looked at common gene variants, the total genetic overlap between the disorders is likely higher,» explained Naomi Wray, Ph.D., University of Queensland, Brisbane, Australia, who co-led the multi-site study by the Cross Disorders Group of the Psychiatric Genomics Consortium (PGC), which is supported by the NIH's National Institute of Mental Health (NIMH).

Psychiatrist Jon McClellan and geneticist Mary - Claire King, both of the University of Washington, Seattle, wrote earlier this month that genome - wide association studies (GWAS), which scan large stretches of the genomes of hundreds of people for common gene variants driving common diseases, aren't getting us very far.

Since the GWAS approach is designed to identify relatively common gene variants and it has been proposed that OCD and TS might be influenced by a number of rare variants, the research team adopted a different method.

In each case they checked tiny sites of known DNA - sequence variations — «single nucleotide polymorphisms» — that mark common gene variants.

ASHG 2015: Common Gene Variant Linked to Chromosome Errors and Early Pregnancy Loss ASHG Press Release — October 8, 2015

Common gene variants that have minor effects may contribute about half the risk of developing autism

First, autism may not be rigidly determined but instead may be related to common gene variants, called polymorphisms, that may be derailed by environmental triggers.

In her most recent study, published in the American Journal of Medical Genetics in 2006, James found that common gene variants that support the glutathione pathway may be associated with autism risk.

«While this study does not show that these common gene variants produce schizophrenia per se, it elegantly suggests that these variants may contribute to declines in intelligence, a clinical feature associated with schizophrenia,» commented Dr. John Krystal, Editor of Biological Psychiatry.

Prior to joining CRI, Vanessa was a postdoctoral fellow at NYU School of Medicine, studying the role of a common gene variant and its effects on Graft - Versus - Host - Disease.

The NIMH study also for the first time confirms in living humans that activity of the front brain area, the prefrontal cortex, is regulated by dopamine production in the midbrain, which, in turn, is regulated by these two common gene variants.