Sentences with phrase «common risk alleles»

In addition, the clinical sensitivity of tests for common risk alleles is not necessarily high.

Common risk alleles with a known association with a condition can inform an individual of an increased or decreased risk of developing the condition in question; however, the degree of certainty is often unknown.

Use of common risk alleles for changes in clinical management can be challenging without a professional guideline.

Common risk alleles are often detected by genome - wide association studies (GWAS) 1,2.

The MAF of common risk alleles can range from 5 % to 50 %.

These limitations can make the interpretation of common risk alleles challenging.

The presence of a common risk allele can indicate a need for increased surveillance, while a negative result implies a risk similar to the general population.

The impact of a common risk allele with disease risk is often modest, as is its impact on clinical care.

Not exact matches

No common BRCA mutations, no APOE risk alleles.

Performing genetic studies in multiple human populations can identify disease risk alleles that are common in one population but rare in others, with the potential to illuminate pathophysiology, health disparities, and the population genetic origins of disease alleles.

In contrast, more than 70 other common alleles have been associated with breast cancer susceptibility, most of which confer only a mild to moderate increase in risk.

However, caution should be used in aggressively selecting against mutant alleles which have low penetrance or low risk for the disease state when the mutant alleles are common throughout the breed.

The associated alleles were common in the studied populations and all had only small effects on disease risk [123].