Researchers have discovered how dopamine — a molecule important
for communication between neurons in the brain — stimulates the synthesis of proteins in neuronal processes.
McGill University researchers have discovered a cellular mechanism that may contribute to the breakdown
of communication between neurons in Alzheimer's disease.
The results support the view that human brain evolution involved cellular specializations, including the elaboration of astrocyte structure and a boost in their ability to
regulate communication between neurons at synapses, the researchers say.
The research has clarified how damaged synapses — the connection points between neurons — are repaired to keep
communication between neurons at an optimal level.
Focusing on this area of the brain, scientists found that expression of TMEM108 and its protein normally increased in the first few weeks of life in a mouse — which would equate to the first few years in a human — critical periods of development that would enable plenty of mature spines and
great communication between neurons.
Mutations in a gene that should enable memories and a sense of direction instead can result in
imprecise communication between neurons that contributes to symptoms of schizophrenia, scientists report.
«But our study found that propofol also disrupts presynaptic mechanisms, probably
affecting communication between neurons across the entire brain in a systematic way that differs from just being asleep.
Because this mechanism is localized at synapses, the sites
where communication between neurons takes place, it ensures that protective measures will only be taken when and where they're most needed, said Marta Margeta, MD, PhD, assistant professor of pathology and senior author of the new study.
In 1999, Scheller demonstrated that calcium triggering and the full formation of the SNARE complex are closely associated, thereby providing the first direct evidence that SNARE complex formation drives the fusion event responsible for neurotransmitter release and the
consequent communication between neurons.
The group of Jean - Louis Bessereau is investigating the molecular organization of chemical synapses, which are the specialized structures
supporting communication between neurons in the brain and between neurons and muscles at neuromuscular junctions.
The brain is largely made up of fat, and the fats we eat directly affect its structure and function, providing insulation around nerve cells, supporting neurotransmitter production, and helping maintain
healthy communication between neurons.
Alzheimer's disease is pathologically characterized as a reduction in brain volume, commonly referred to as shrinkage, as well as amyloid protein tangles that prevent
efficient communication between neurons by altering chemical and electrical signaling.
This finding, which opens up a new line of investigation in the area of physiopathology, has led the scientists of the UCA to show that in physiological conditions this molecule
regulates communication between neurons.
As the venom snips the lines
of communication between the neurons and muscle, the drugs work to enhance the signal — like sending a surge of electricity down an increasingly fraying wire.
According to Cheyette, this is some of the strongest evidence to date that WNT signaling could play a key role in driving psychiatric disease, and that it works through changes in
synaptic communication between neurons.
Why the illness appears earlier in some is a mystery, but there is evidence that some children (1 in 1,000) may develop the disorder after a strep infection, when an antibody generated to fight the bacteria mistakenly turns against a brain enzyme and
disrupts communication between neurons.
When the researchers examined the brains of the treated elderly mice for an explanation, they noticed that neurons in the hippocampus — a brain area critical for learning and memory — had sprouted more synaptic spines, the points of contact for
communication between neurons.
Action potentials can be created by many types of cells, but are used most extensively by the nervous system for
communication between neurons and to transmit information from neurons to other body tissues such as muscles and glands.
The post-synaptic density is a specialized area full of proteins needed for
communication between neurons, so changes in its structure or capacity may explain the aberrant electrical responses.
Boyden said there is considerable interest in brain regions that are important for learning or addiction — learning gone wrong — with particular attention to small groups of neurons deep in the brain that manufacture dopamine, a chemical transmitter involved in regulating
communication between neurons.
Nguyen plans on applying IM - LARIAT technology to a living brain, where she would be able to control synaptic vesicle transmission and
communication between neurons.
«New mechanism detected in Alzheimer's disease: Rate of RNA decay could be a key to breakdown in
communication between neurons.»
A team of researchers led by professor Patrik Verstreken (VIB / KU Leuven) has exposed the fine details of a mechanism that provides more insight in
the communication between neurons.
Axons are tendrils projecting from the neuron, which are essential for
communication between neurons.
Instead, alcohol damages the dendrites located in the cerebellum and reduces
the communication between neurons.
A cellular protein called PAK1 stimulates the growth of dendritic spines, or protrusions, that allow
communication between neurons, and Roy had a hunch that this protein — when transported into brain cells — might help bring silent engrams back into direct awareness.
«In addition to microcephaly, infection with Zika virus in adults can lead to destruction of myelin, a mixture of proteins and fatty substances that insulate nerves to speed electrical
communication between neurons, a condition called Guillain - Barre syndrome.»
The researchers investigated whether
this communication between neurons is disrupted in AD - mice, and if so, how this may affect the symptoms of Alzheimer's disease.