Sentences with phrase «comparative genomic»

As computational biologists, they employ comparative genomic approaches to understand the evolution and function of protein families and their ultimate role in human disease.

44) Lockwood WW *, †, Chari R *, Chi B, Lam WL (2006) Recent advances in array comparative genomic hybridization technologies and their applications in human genetics.

Already, comparative genomic analysis of six species of yeast has prompted scientists to significantly revise their initial catalog of yeast genes and to predict a new set of functional elements thought to play a role in regulating genome activity.

43) Chari R *, Lockwood WW *, Lam WL (2006) Computational methods for the analysis of array comparative genomic hybridization.

The Comparative Genomic group focuses on the characterization and interpretation of genomic differences in phenotypically different genomes.

1) Coe BP, Lockwood WW, Chari R, Lam WL (2009) Comparative genomic hybridization on BAC arrays.

Cross-species array comparative genomic hybridization identifies novel oncogenic events in zebrafish and human embryonal rhabdomyosarcoma.

Using our own data and publically available data from array comparative genomic hybridization (aCGH), we identified a minimal deletion for the cardiomyopathy associated with del1p36 that included only the terminal 14 exons of the transcription factor PRDM16 (PR domain containing 16), a gene that had previously been shown to direct brown fat determination and differentiation.

Most receptors are annotated from comparative genomic studies [8], which means non-coding UTRs are frequently missing.

Further comparative genomic and transcriptomic analyses showed infection severity correlated with the expression levels of certain genes shared by nearly all E. coli, including genes involved in motility and nutrient utilization.

Third, genes involved in pheromone detection are often species - specific and functional orthologues are typically lacking in the human genome, which confound their detection by comparative genomic methods [22].

For more on comparative genomic analysis, go to: Background on Comparative Genomic Analysis.

The draft genome sequence of a Great Barrier Reef demosponge Amphimedon queenslandica is reported, together with comparative genomic analysis.

There is also growing evidence that the protein - coding repertoire of the innate immune system is rapidly evolving in insects [5], [8]--[11], even though comparative genomic analysis reveals the existence of a conserved core of immune signaling pathways in most insects [12]--[15].

I took these comparative genomic scans to the next level by writing a computer program to identify DNA sequences that are conserved in other animals but have changed rapidly in humans since we evolved from our common ancestor with chimpanzees.

Comparative genomic hybridization showed a normal pattern in the first case and a gain of chromosomal 12 in the xenografted tumor.

Another distinctive genetic feature of mucosal melanoma is its high rate of copy number and structural variants, demonstrated both by array - based comparative genomic hybridization and whole - genome sequencing.

The goal of this project is to identify the specific nucleotide sequences and / or single nucleotide polymorphisms that are correlated with expression of virulence and disease via comparative genomic analysis between B. pseudomallei strains as well as between various bacteriophages harbored within B. pseudomallei.

Environmental adaptation of Acanthamoeba castellanii and Entamoeba histolytica at genome level as seen by comparative genomic analysis Victoria Shabardina, Tabea Kischka, Hanna Kmita, Yutaka Suzuki, Wojciech Makałowski International Journal of Biological Sciences 2018; 14:306 - 320

Comparative genomic analysis of the multispecies probiotic - marketed product VSL # 3 — François P. Douillard — Plos One

He works with Dr. Andrew Paterson on constructing and characterizing physical and genetic maps of crop plants in the genus Brassica and also works on a database to advance comparative genomic analysis of the Brassica.

The high resolution that is achieved by these techniques, particularly by microarray technologies such as array comparative genomic hybridization, is blurring the traditional distinction between cytogenetics and molecular biology.

Adding them to the five disease - derived EBV genomic sequences available in the literature, we performed an in - depth comparative genomic analysis.

Comparative genomic analysis from 82 wild and wild - derived species grouped by microhabitat - use identified variation corresponding with one of these QTL, further supporting broad association with habitat use across the Malawi cichlid radiation.

Professor Matt Bellgard has developed expertise in the areas of comparative genomic analysis, computational biology, molecular evolution, bioinformatics, integrated system development and pattern recognition.

Firstly, both species have well characterised genomes with highly accurate and well annotated assemblies [5, 17] and have both been used frequently in comparative genomic analyses resulting in many easily accessible pairwise alignment datasets available on the UCSC genome browser [18].

These include two flagship papers: one exploiting genomic - scale data to generate a highly supported avian order phylogeny that resolves many debates on the timing and topology of their radiation; the other a comparative genomic analysis exploring avian genome evolution and the genetic basis of complex traits.

Branscomb also sees lots of opportunities in «techniques that are transforming scientific methodology, such as array technology, comparative genomic approaches, proteomics, sequence analysis.»

Gain a deeper understanding of array comparative genomic hybridization, how it works and how it is being applied in clinical research today.

Array comparative genomic hybridization (aCGH) takes the concept of CGH and moves it onto the high throughput medium of a glass slide.

But Alan Bittles, adjunct professor at the centre for comparative genomics at Murdoch University and fellow of the American Association for the Advancement of Science, responded: «There's a level of arrogance in comparing a smoking campaign with interfering in people's intimate relationships.»

Comparative genomics research like this has only been possible in the past couple of years as the genome sequences of snakes and other species have become available.

«Our study provides an example of the utility of comparative genomics and evolutionary models for medicine,» Sunyaev said.

But the team discovered through its comparative genomics of various microorganisms that Xanthomonas oryzae — a pathogenic bacteria that causes rice plant leaves to turn white before killing the plant — does not have Glu racemase genes.

Comparative genomics based on massive parallel transcriptome sequencing reveals patterns of substitution and selection across 10 bird species

«People have shown with comparative genomics that novel genes can be involved in novel structures.

Comparative genomics of the tardigrades Hypsibius dujardini and Ramazzottius varieornatus.

The development of «bioinformatic packages» for the analysis of genetic variability and genotype - phenotype relationships will be of great value for any basic and applied comparative genomics research issues.

«This [work] opens the way for comparative genomics and identification of [unique features] in this group of ecological and economically important species,» says Etienne Danchin, an evolutionary biologist at the National Institute of Agricultural Research in Sophia - Antipolis, France, who was not involved with the research.

«We think the power of comparative genomics can be fully exploited only when there are thousands of genomes available,» Grishin said.

Other projects focused on neuroscience, comparative genomics, and behavioral research.

The comparative genomics analysis could «backtrack» the history of their genes, and showed that the two bacteria have diverged 13.9 million years ago from a common ancestor with a similar genome structure, and possibly a similar lifestyle.

The working group also recommended ending five of 13 comparative genomics and behavioral studies that use 10 of about 300 animals.

Studies like these have spurred the field of comparative genomics, as scientists seek to better understand relationships between species and how they evolved.

Using comparative genomics, the research team noticed that P. destructans lacked a key DNA repair enzyme, prompting them to expose the fungi to DNA damaging agents, including different wavelengths and intensities of UV light.

In addition to medical sequencing and technology development efforts, the sequencing research network will continue its groundbreaking work in comparative genomics, which involves sequencing and comparing the genomes of various organisms.

Comparative genomics reveals that Cryptococcus species contain the meiotic genes involved in homologous recombination and synaptonemal complex formation [46], [58].

The International Oryza Map Alignment Project: development of a genus - wide comparative genomics platform to help solve the 9 billion - people question

Alu - insertion polymorphisms are a boon for the study of human population genetics and primate comparative genomics because they are neutral genetic markers of identical descent with known ancestral states.

Kerstin Lindblad - Toh, professor in comparative genomics and director at SciLifeLab in Uppsala, has led the studies where an international consortium of researchers mapped the coelacanth genome and compared it with the DNA of terrestrial vertebrates.