Sentences with phrase «compare models of disease»
The NIH Roadmap Project should help by allowing them to compare models of disease with reference samples.
https://www.scientificamerican.com/ Not exact matches
Comparing different policy scenarios to reduce the consumption of ultra-processed foods in UK: impact on cardiovascular disease mortality using a modelling approach
Another problem is that modeling studies, like this one, are inherently less powerful than other kinds of medical research: randomized clinical trials, the gold standard in medical research, in which patients are randomly assigned different treatments or no treatment; case - control studies, which compare patients who have a condition with those who do not; or cohort studies, which determine the risk of contracting a disease by studying a group of people with similar demographics.
In future, the lab plans to compare aging astrocytes to astrocytes in models of disease to see whether there could be prepathological changes that allow the transition to disease to occur.
«We compared the ability of RSV and parainfluenza virus (PIV3)-- another common virus in children that causes much less severe airway disease — to infect and cause inflammatory responses in a cell culture model of human epithelial cells, which compose the lining of the lung airway.
In a mouse model of Alzheimer's disease, Salk Institute researchers show that raising levels of neuregulin - 1 (right) lowers a marker of disease pathology in a part of the brain that controls memory compared with controls (left).
Combining chemotherapy and birinapant significantly improved disease - free survival in laboratory models of human ovarian cancer compared to using either therapy alone.
It's now possible to not only model disease using the cells, but also to compare iPSCs from humans to those of our closest living relatives --- great apes, with which we share a majority of genes --- for insight into what molecular and cellular features make us human.
The international team of researchers modeled the lifetime risk of women developing radiation - induced breast cancer from digital screening mammography and dying from the disease compared to the number of breast cancer deaths prevented by early detection.
To create cell models for the discovery of disease etiology, progression, and treatment, isogenic cell lines can be created from healthy or sick individuals, then compared (Figure 1).
In a Cox proportional hazards model adjusting for age, examination years and all other predictive coronary disease risk factors, blood donors had a 88 % reduced risk (relative hazard = 0.12, 95 % confidence interval 0.02 - 0.86, p = 0.035) of acute myocardial infarction, compared with non-blood donors.
The researchers looked at the dentate gyrus, a specific area of the brain that is critical to memory and particularly vulnerable in Alzheimer's disease, and compared the genes that were turned on and off in normal mice and a mouse model of Alzheimer's disease.
For such study, we have used the McGill - R - Thy1 - APP transgenic rat, which is unique compared to other rodent models in that the AD - like phenotype has been achieved with a single genomic insertion of a mutated human APP transgene; minimizing off - target genetic corruption and therefore being closer to the human disease [32].
Furthermore, I plan to construct models that will describe how ecosystem structure may change in the face of multiple stressors, and compare these models against existing models of coral bleaching and disease to determine whether they offer novel insights or enhanced predictive ability of these events.
Invasive disease models in Galleria mellonella and SPEC - sensitive transgenic mice, revealed no difference in overall invasiveness of Lineage C ST15 strains compared to non-Lineage C ST15 strains, consistent with clinical and epidemiological analysis.
Furthermore, the heterozygous knock in mouse serves as a better animal model of the human disorder, as compared to the homozygous mouse, given that Huntington disease homozygosity is very rare in humans.
A new and more disease relevant animal model of diabetes polyneuropathy, the ZDF model, has now been further validated and compared to other models of diabetes polyneuropathy.
The research lines of the Bakkers group include unraveling the genetics of normal cardiac development and body axis formation during development, investigating the molecular mechanisms of heart regeneration in the zebrafish and how this can be compared to heart injury in the mammals, and modeling of human (cardiac) disease in the zebrafish to unravel biological mechanisms behind the disease and to identify new drug targets.
Furthermore, in an animal model of Huntington's disease, prolonged survival, reduced disease - associated weight loss and improved motor function was observed in animals on an alternate - day fasting diet compared to animals fed ad libitum (49).
The Effect of Acetyl - L - carnitine and R - alpha - lipoic acid Treatment in ApoE4 Mouse as a Model of Human Alzheimer's Disease J Neurol Sci 2009 (Mar 31)[Epub ahead of print] We measured age - dependent effects of human ApoE4 on cerebral blood flow (CBF) using ApoE4 transgenic mice compared to age - matched wild - type (WT) mice by use of -LSB-(14) C] iodoantipyrene autoradiography.
On this basis, a ketogenic diet has been proposed as a collateral therapeutic approach in this disease.95 Studies by Zhao et al. 96 revealed both histological and functional improvements in an animal model of amyotrophic lateral sclerosis when a ketogenic diet was given compared with when given a control diet.