The need to
compare multiple cells» DNA sequences to distinguish genuine genetic variants from artifacts limits some of the potential of single - cell sequencing.
Not exact matches
Analyzing a database of nearly 800
multiple myeloma patient samples, they discovered that 162 patients with low ADAR1 levels in their tumor
cells survived significantly longer over a three - year period
compared to 159 patients with high ADAR1 levels.
For this analysis, 605 patients with newly diagnosed
multiple myeloma and treated with continuous lenalidomide (brand name Revlimid) following autologous stem
cell transplant were
compared to 604 patients who were treated with placebo or no maintenance.
Comparing the metastasized tumors with the original breast tumors, the researchers were surprised to learn that
multiple, slightly genetically different
cells from the original site had broken away together and established the new tumors.
The researchers then
compared tumor
cells isolated from
multiple different breast cancer patients and found that
cells expressing lower amounts of Numb - 1 and -2 were more resistant to the chemotherapy agent cisplatin.
The study
compared multiple techniques — or assays — used to analyze genomic data from a glioblastoma patient's tumor
cells and normal healthy
cells.
We
compared the
cell - fractions of pre - and post-mortem samples globally using the Anderson — Darling test53 and by
cell - type obtaining a p - value using the two - sided Wilcoxon Rank - Sum test54, adjusted to
multiple - testing by Benjamini — Hochberg method44.
In the study, the researchers
compared how well CRISPRi and CRISPR - Cas9 silenced a particular gene that controls iPSC pluripotency — the capability of iPSCs to turn into
multiple cell types.