Sentences with phrase «compared whole genome sequencing»

By comparing the whole genome sequence of the lab - cultured resistant strain with a sibling strain that had not been exposed to the drug, they were able to identify several mutations of interest in a number of genes.

Not exact matches

The team integrated three, complementary gene sequencing approaches to look for mutations in tumor cells from SS patients: whole - genome sequencing in six subjects, sequencing of all protein - coding regions (exomes) in 66 subjects, and comparing variation in the number of copies of all genes across the genome in 80 subjects.

To grasp the implications, Stefánsson's team compared the whole - genome sequences of 78 Icelandic people diagnosed with autism or schizophrenia with the sequences of their fathers and mothers.

Using whole - genome sequencing, they looked at rare genetic variants in modern - day British populations and compared them with variants in the DNA of 10 ancient skeletons.

The team used whole genome sequencing techniques to compare the genetic information from the TB bacteria of each patient.

Chowdhury and his colleagues found that for all six infants, who suffered from a variety of often exceedingly rare genetic disorders, sequencing their whole genomes led to a reduction in the length of stay in the NICU by 124 days compared to control cases and reports from the scientific literature, in which standard array or panel - based genetic testing may be used.

A cohort like the one in the AMD study (44,000 samples) probably costs $ 2.2 million to genotype, compared to sequencing costs of $ 9.7 million (exome) to $ 45 million (whole genome).

Compared to whole - genome sequencing, the authors claim a 20-fold reduction in the amount of sequence required.

A number of earlier studies have compared a subset of those sequencing platforms or compared those platforms with Sanger sequencing, which is prohibitively expensive for whole genome studies.

These studies, however, were based on comparing Life Technologies» SOLiD and Illumina's GAII with pyrosequencing or Sanger sequencing [8], [9], [10], the costs of which are prohibitive for whole - genome sequencing studies in mammals.